Structure-based inhibitors of amyloid beta core suggest a common interface with tau.

Griner SL, Seidler P, Bowler J, Murray KA, Yang TP, Sahay S, Sawaya MR, Cascio D, Rodriguez JA, Philipp S, Sosna J, Glabe CG, Gonen T, Eisenberg DS

Elife, 8:e46924, 15 Oct 2019

Cited by: 47 articles | PMID: 31612856 | PMCID: PMC6850776

CryoEM structure of the low-complexity domain of hnRNPA2 and its conversion to pathogenic amyloid.

Lu J, Cao Q, Hughes MP, Sawaya MR, Boyer DR, Cascio D, Eisenberg DS

Nat Commun, 11(1):4090, 14 Aug 2020

Cited by: 46 articles | PMID: 32796831 | PMCID: PMC7427792

Cryo-EM structure of a human prion fibril with a hydrophobic, protease-resistant core.

Glynn C, Sawaya MR, Ge P, Gallagher-Jones M, Short CW, Bowman R, Apostol M, Zhou ZH, Eisenberg DS, Rodriguez JA

Nat Struct Mol Biol, 27(5):417-423, 13 Apr 2020

Cited by: 45 articles | PMID: 32284600 | PMCID: PMC7338044

Atomic-level evidence for packing and positional amyloid polymorphism by segment from TDP-43 RRM2.

Guenther EL, Ge P, Trinh H, Sawaya MR, Cascio D, Boyer DR, Gonen T, Zhou ZH, Eisenberg DS

Nat Struct Mol Biol, 25(4):311-319, 12 Mar 2018

Cited by: 44 articles | PMID: 29531287 | PMCID: PMC6056015

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Cryo-EM structures of hIAPP fibrils seeded by patient-extracted fibrils reveal new polymorphs and conserved fibril cores.

Cao Q, Boyer DR, Sawaya MR, Abskharon R, Saelices L, Nguyen BA, Lu J, Murray KA, Kandeel F, Eisenberg DS

Nat Struct Mol Biol, 28(9):724-730, 09 Sep 2021

Cited by: 39 articles | PMID: 34518699 | PMCID: PMC10396428

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Inhibition of synucleinopathic seeding by rationally designed inhibitors.

Sangwan S, Sahay S, Murray KA, Morgan S, Guenther EL, Jiang L, Williams CK, Vinters HV, Goedert M, Eisenberg DS

Elife, 9:e46775, 02 Jan 2020

Cited by: 33 articles | PMID: 31895037 | PMCID: PMC6977966

Inhibiting amyloid-β cytotoxicity through its interaction with the cell surface receptor LilrB2 by structure-based design.

Cao Q, Shin WS, Chan H, Vuong CK, Dubois B, Li B, Murray KA, Sawaya MR, Feigon J, Black DL, Eisenberg DS, Jiang L

Nat Chem, 10(12):1213-1221, 08 Oct 2018

Cited by: 31 articles | PMID: 30297750 | PMCID: PMC6250578

Structure-based inhibitors halt prion-like seeding by Alzheimer's disease-and tauopathy-derived brain tissue samples.

Seidler PM, Boyer DR, Murray KA, Yang TP, Bentzel M, Sawaya MR, Rosenberg G, Cascio D, Williams CK, Newell KL, Ghetti B, DeTure MA, Dickson DW, Vinters HV, Eisenberg DS

J Biol Chem, 294(44):16451-16464, 19 Sep 2019

Cited by: 29 articles | PMID: 31537646 | PMCID: PMC6827308

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Structure of amyloid-β (20-34) with Alzheimer's-associated isomerization at Asp23 reveals a distinct protofilament interface.

Warmack RA, Boyer DR, Zee CT, Richards LS, Sawaya MR, Cascio D, Gonen T, Eisenberg DS, Clarke SG

Nat Commun, 10(1):3357, 26 Jul 2019

Cited by: 28 articles | PMID: 31350392 | PMCID: PMC6659688

Cryo-EM structure of RNA-induced tau fibrils reveals a small C-terminal core that may nucleate fibril formation.

Abskharon R, Sawaya MR, Boyer DR, Cao Q, Nguyen BA, Cascio D, Eisenberg DS

Proc Natl Acad Sci U S A, 119(15):e2119952119, 04 Apr 2022

Cited by: 26 articles | PMID: 35377792 | PMCID: PMC9169762

De novo designed protein inhibitors of amyloid aggregation and seeding.

Murray KA, Hu CJ, Griner SL, Pan H, Bowler JT, Abskharon R, Rosenberg GM, Cheng X, Seidler PM, Eisenberg DS

Proc Natl Acad Sci U S A, 119(34):e2206240119, 15 Aug 2022

Cited by: 23 articles | PMID: 35969734 | PMCID: PMC9407671

Intrinsic electronic conductivity of individual atomically resolved amyloid crystals reveals micrometer-long hole hopping via tyrosines.

Shipps C, Kelly HR, Dahl PJ, Yi SM, Vu D, Boyer D, Glynn C, Sawaya MR, Eisenberg D, Batista VS, Malvankar NS

Proc Natl Acad Sci U S A, 118(2):e2014139118, 01 Jan 2021

Cited by: 21 articles | PMID: 33372136 | PMCID: PMC7812754

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A pair of peptides inhibits seeding of the hormone transporter transthyretin into amyloid fibrils.

Saelices L, Nguyen BA, Chung K, Wang Y, Ortega A, Lee JH, Coelho T, Bijzet J, Benson MD, Eisenberg DS

J Biol Chem, 294(15):6130-6141, 07 Feb 2019

Cited by: 21 articles | PMID: 30733338 | PMCID: PMC6463714

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Identification of two principal amyloid-driving segments in variable domains of Ig light chains in systemic light-chain amyloidosis.

Brumshtein B, Esswein SR, Sawaya MR, Rosenberg G, Ly AT, Landau M, Eisenberg DS

J Biol Chem, 293(51):19659-19671, 24 Oct 2018

Cited by: 16 articles | PMID: 30355736 | PMCID: PMC6314132

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Prevalence and species distribution of the low-complexity, amyloid-like, reversible, kinked segment structural motif in amyloid-like fibrils.

Hughes MP, Goldschmidt L, Eisenberg DS

J Biol Chem, 297(4):101194, 16 Sep 2021

Cited by: 15 articles | PMID: 34537246 | PMCID: PMC8551513

Crystal structure of a conformational antibody that binds tau oligomers and inhibits pathological seeding by extracts from donors with Alzheimer's disease.

Abskharon R, Seidler PM, Sawaya MR, Cascio D, Yang TP, Philipp S, Williams CK, Newell KL, Ghetti B, DeTure MA, Dickson DW, Vinters HV, Felgner PL, Nakajima R, Glabe CG, Eisenberg DS

J Biol Chem, 295(31):10662-10676, 03 Jun 2020

Cited by: 13 articles | PMID: 32493775 | PMCID: PMC7397112

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Structural polymorphism of amyloid fibrils in ATTR amyloidosis revealed by cryo-electron microscopy.

Nguyen BA, Singh V, Afrin S, Yakubovska A, Wang L, Ahmed Y, Pedretti R, Fernandez-Ramirez MDC, Singh P, Pękała M, Cabrera Hernandez LO, Kumar S, Lemoff A, Gonzalez-Prieto R, Sawaya MR, Eisenberg DS, Benson MD, Saelices L

Nat Commun, 15(1):581, 17 Jan 2024

Cited by: 12 articles | PMID: 38233397 | PMCID: PMC10794703

Small molecules disaggregate alpha-synuclein and prevent seeding from patient brain-derived fibrils.

Murray KA, Hu CJ, Pan H, Lu J, Abskharon R, Bowler JT, Rosenberg GM, Williams CK, Elezi G, Balbirnie M, Faull KF, Vinters HV, Seidler PM, Eisenberg DS

Proc Natl Acad Sci U S A, 120(7):e2217835120, 09 Feb 2023

Cited by: 12 articles | PMID: 36757890 | PMCID: PMC9963379

Identifying amyloid-related diseases by mapping mutations in low-complexity protein domains to pathologies.

Murray KA, Hughes MP, Hu CJ, Sawaya MR, Salwinski L, Pan H, French SW, Seidler PM, Eisenberg DS

Nat Struct Mol Biol, 29(6):529-536, 30 May 2022

Cited by: 11 articles | PMID: 35637421 | PMCID: PMC9205782

Structure-based design of nanobodies that inhibit seeding of Alzheimer's patient-extracted tau fibrils.

Abskharon R, Pan H, Sawaya MR, Seidler PM, Olivares EJ, Chen Y, Murray KA, Zhang J, Lantz C, Bentzel M, Boyer DR, Cascio D, Nguyen BA, Hou K, Cheng X, Pardon E, Williams CK, Nana AL, Vinters HV, [...] Eisenberg DS

Proc Natl Acad Sci U S A, 120(41):e2300258120, 06 Oct 2023

Cited by: 9 articles | PMID: 37801475 | PMCID: PMC10576031

Mechanically rigid supramolecular assemblies formed from an Fmoc-guanine conjugated peptide nucleic acid.

Basavalingappa V, Bera S, Xue B, Azuri I, Tang Y, Tao K, Shimon LJW, Sawaya MR, Kolusheva S, Eisenberg DS, Kronik L, Cao Y, Wei G, Gazit E

Nat Commun, 10(1):5256, 20 Nov 2019

Cited by: 8 articles | PMID: 31748568 | PMCID: PMC6868146

Atomic insights into the genesis of cellular filaments by globular proteins.

McPartland L, Heller DM, Eisenberg DS, Hochschild A, Sawaya MR

Nat Struct Mol Biol, 25(8):705-714, 03 Aug 2018

Cited by: 5 articles | PMID: 30076408 | PMCID: PMC6185745

Low complexity domains of the nucleocapsid protein of SARS-CoV-2 form amyloid fibrils.

Tayeb-Fligelman E, Bowler JT, Tai CE, Sawaya MR, Jiang YX, Garcia G, Griner SL, Cheng X, Salwinski L, Lutter L, Seidler PM, Lu J, Rosenberg GM, Hou K, Abskharon R, Pan H, Zee CT, Boyer DR, Li Y, [...] Eisenberg DS

Nat Commun, 14(1):2379, 25 Apr 2023

Cited by: 4 articles | PMID: 37185252 | PMCID: PMC10127185

D-peptide-magnetic nanoparticles fragment tau fibrils and rescue behavioral deficits in a mouse model of Alzheimer's disease.

Hou K, Pan H, Shahpasand-Kroner H, Hu C, Abskharon R, Seidler P, Mekkittikul M, Balbirnie M, Lantz C, Sawaya MR, Dolinsky JL, Jones M, Zuo X, Loo JA, Frautschy S, Cole G, Eisenberg DS

Sci Adv, 10(18):eadl2991, 01 May 2024

Cited by: 1 article | PMID: 38691615 | PMCID: PMC11062580

Author Correction: Inhibiting amyloid-β cytotoxicity through its interaction with the cell surface receptor LilrB2 by structure-based design.

Cao Q, Shin WS, Chan H, Vuong CK, Dubois B, Li B, Murray KA, Sawaya MR, Feigon J, Black DL, Eisenberg DS, Jiang L

Nat Chem, 10(12):1267, 01 Dec 2018

Cited by: 1 article | PMID: 30420778 | PMCID: PMC7124629

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Fibril structures of TFG protein mutants validate the identification of TFG as a disease-related amyloid protein by the IMPAcT method.

Rosenberg GM, Abskharon R, Boyer DR, Ge P, Sawaya MR, Eisenberg DS

PNAS Nexus, 2(12):pgad402, 20 Nov 2023

Cited by: 0 articles | PMID: 38077690 | PMCID: PMC10703350

Cryo-EM structure of RNA-induced tau fibrils reveals a small C-terminal core that may nucleate fibril formation

Abskharon R, Sawaya MR, Boyer DR, Cao Q, Nguyen BA, Cascio D, Eisenberg DS

bioRxiv, 28 Jan 2022

Cited by: 0 articles | PPR: PPR448054

Preprint

The prevalence and distribution in genomes of low-complexity, amyloid-like, reversible, kinked segment (LARKS), a common structural motif in amyloid-like fibrils

Hughes MP, Goldschmidt L, Eisenberg DS

bioRxiv, 08 Dec 2020

Cited by: 0 articles | PPR: PPR250497

Preprint

The cryoEM structure of the fibril-forming low-complexity domain of hnRNPA2 reveals distinct differences from pathogenic amyloid and shows how mutation converts it to the pathogenic form

Lu J, Cao Q, Hughes MP, Sawaya MR, Boyer DR, Cascio D, Eisenberg DS

bioRxiv, 25 May 2020

Cited by: 0 articles | PPR: PPR167296

Preprint

Author Correction: Atomic structures of TDP-43 LCD segments and insights into reversible or pathogenic aggregation.

Guenther EL, Cao Q, Trinh H, Lu J, Sawaya MR, Cascio D, Boyer DR, Rodriguez JA, Hughes MP, Eisenberg DS

Nat Struct Mol Biol, 26(10):988, 01 Oct 2019

Cited by: 0 articles | PMID: 31530939 | PMCID: PMC7103477

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Cryo-EM Structures of Four Polymorphic TDP-43 Amyloid Cores

Cao Q, Boyer DR, Sawaya MR, Ge P, Eisenberg DS

bioRxiv, 06 Apr 2019

Cited by: 0 articles | PPR: PPR75441

Preprint

A structure-based model for the electrostatic interaction of the N-terminus of protein tau with the fibril core of Alzheimer’s Disease filaments

Boyer DR, Eisenberg DS

bioRxiv, 30 Nov 2018

Cited by: 0 articles | PPR: PPR63515

Preprint