Parkin (protein): Difference between revisions

'''Parkin''' is a [[protein]] which in humans is encoded by the ''PARK2'' [[gene]].<ref name="pmid9560156">{{cite journal | author = Kitada T, Asakawa S, Hattori N, Matsumine H, Yamamura Y, Minoshima S, Yokochi M, Mizuno Y, Shimizu N | title = Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism | journal = Nature | volume = 392 | issue = 6676 | pages = 605–8 | year = 1998 | month = April | pmid = 9560156 | doi = 10.1038/33416 | url = }}</ref><ref name="pmid9570960">{{cite journal | author = Matsumine H, Yamamura Y, Hattori N, Kobayashi T, Kitada T, Yoritaka A, Mizuno Y | title = A microdeletion of D6S305 in a family of autosomal recessive juvenile parkinsonism (PARK2) | journal = Genomics | volume = 49 | issue = 1 | pages = 143–6 | year = 1998 | month = April | pmid = 9570960 | doi = 10.1006/geno.1997.5196 | url = }}</ref> The precise function of this protein is unknown; however, the protein is a component of a multiprotein [[ubiquitin ligase|E3 ubiquitin ligase]] complex which in turn is part of the [[ubiquitin-proteasome system]] that mediates the targeting of proteins for [[proteasome|degradation]] [[citation needed]]. Mutations in this gene are known to cause a familial form of [[Parkinson's disease]] known as autosomal recessive juvenile Parkinson disease.