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Importing Wikidata short description: Protein-coding gene in the species Homo sapiens (shortdescs-in-category) |
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'''Spo11''' is a [[protein]] that in humans is encoded by the ''SPO11'' [[gene]]. Spo11, in a complex with mTopVIB, creates double strand breaks to initiate meiotic [[genetic recombination|recombination]].<ref>{{cite journal | vauthors = Vrielynck N, Chambon A, Vezon D, Pereira L, Chelysheva L, De Muyt A, Mézard C, Mayer C, Grelon M | display-authors = 6 | title = A DNA topoisomerase VI-like complex initiates meiotic recombination | journal = Science | volume = 351 | issue = 6276 | pages = 939–43 | date = February 2016 | pmid = 26917763 | doi = 10.1126/science.aad5196 | bibcode = 2016Sci...351..939V | s2cid = 206643600 | url = https://www.science.org/doi/10.1126/science.aad5196 }}</ref><ref>{{cite journal | vauthors = Robert T, Nore A, Brun C, Maffre C, Crimi B, Bourbon HM, de Massy B | title = The TopoVIB-Like protein family is required for meiotic DNA double-strand break formation | journal = Science | volume = 351 | issue = 6276 | pages = 943–9 | date = February 2016 | pmid = 26917764 | doi = 10.1126/science.aad5309 | bibcode = 2016Sci...351..943R | s2cid = 9445593 | url = https://www.science.org/doi/10.1126/science.aad5309 }}</ref> Its active site contains a tyrosine which ligates and dissociates with DNA to promote break formation. One Spo11 protein is involved per strand of DNA, thus two Spo11 proteins are involved in each double stranded break event.
Genetic exchange between two DNA molecules by [[homologous recombination]]
== Meiotic recombination ==
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