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Principal photography for ''Lorenzo's Oil'' began on September 9, 1991 in [[Ben Avon, Pennsylvania]].<ref>{{cite news|last1=Blank|first1=Ed|title=Producer excited about Ben Avon as site for movie 'Lorenzo's Oil'|url=https://news.google.com/newspapers?nid=1144&dat=19910831&id=vfkjAAAAIBAJ&pg=5983,8208963|access-date=May 12, 2015|work=[[Pittsburgh Press]]|date=August 31, 1991}}</ref>
 
Possibly to emphasize the “everyman"everyman" aspect of the plot (the notion that a cure could affect families and individuals anywhere), many smaller roles were played by inexperienced actors or non-actors with unusual physical features and mannerisms.{{Citation needed|date=September 2022}} For example, the poet [[James Merrill]] was noticed by a casting director at a New York public reading of his poetry. His rarefied speaking cadences were utilized in a symposium scene in which he played a questioning doctor.
 
===Music===