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}}</ref> The actual subject of the film, Lorenzo Odone, died of pneumonia in May 2008 at the age of 30, having lived two decades longer than originally predicted by doctors.<ref>{{cite news|title= Lorenzo loses battle for life but legacy of hope lives on|work= [[The Guardian]]|date=31 May 2008|publisher=Guardian News and Media Ltd|url= https://www.theguardian.com/science/2008/jun/01/medicalresearch.genetics|access-date=2012-10-11}}</ref>
 
[[Hugo Moser (scientist)|Hugo Moser]], on whom the character of Professor Nikolais was based, called the film's portrayal of that characterhim "an abomination".<ref name=MoserObit>{{cite news|title= Hugo Moser, 82; neurologist's portrayal in 'Lorenzo's Oil' belied his real character|work= [[Los Angeles Times]]|date=26 January 2007|url= https://articles.latimes.com/2007/jan/26/local/me-moser26|access-date=2017-05-07}}</ref>
 
===Box office===