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It is typically caused by [[kidney failure]] or is [[iatrogenic|treatment-induced]] such as from [[antacids]] that contain magnesium.<ref name=EU2010/><ref>{{cite book| first1=Andrea, M.P.| last1=Romani|editor=Astrid Sigel|editor2=Helmut Sigel|editor3=Roland K. O. Sigel|title=Interrelations between Essential Metal Ions and Human Diseases|series=Metal Ions in Life Sciences|volume=13|year=2013|publisher=Springer|pages=49–79|chapter=Chapter 3. Magnesium in Health and Disease|doi=10.1007/978-94-007-7500-8_3| pmid=24470089}}</ref> Less common causes include [[tumor lysis syndrome]], [[seizures]], and prolonged [[ischemia]].<ref name=Ron2017/> Diagnosis is based on a blood level of magnesium greater than 1.1[[Mole (unit)| mmol]]/L (2.6 mg/dL).<ref name=EU2010/><ref name=Mer2018/> It is severe if levels are greater than 2.9 mmol/L (7 mg/dL).<ref name=Ed2011>{{cite book |last1=Lerma |first1=Edgar V. |last2=Nissenson |first2=Allen R. |title=Nephrology Secrets |date=2011 |publisher=Elsevier Health Sciences |isbn=978-0323081276 |page=568 |url=https://books.google.com/books?id=d6LlS7XBS2YC&pg=PA568 |language=en}}</ref> Specific [[electrocardiogram]] (ECG) changes may be present.<ref name=EU2010/>
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