Lung compliance

Pulmonary compliance is calculated using the following equation, where ΔV is the change in volume, and ΔP is the change in pleural pressure:

${\displaystyle Compliance={\frac {\Delta V}{\Delta P}}}$ 

For example, if a patient inhales 500 mL of air from a spirometer with an intrapleural pressure before inspiration of −5 cm H₂O and −10 cm H₂O at the end of inspiration. Then:

${\displaystyle Compliance={\frac {\Delta V}{\Delta P}}={\frac {.5\;{\ce {L}}}{-5\;{\ce {cm\,H2O}}-(-10\;{\ce {cm\,H2O}})}}={\frac {.5\;{\ce {L}}}{5\;{\ce {cm\,H2O}}}}=0.1\;{\ce {L}}\;\times \;{\ce {cm\,H2O^{-1}}}}$ 

Static compliance represents pulmonary compliance during periods without gas flow, such as during an inspiratory pause. It can be calculated with the formula:

${\displaystyle C_{stat}={\frac {V_{T}}{P_{plat}-\mathrm {PEEP} }}}$ 

where

V_T = tidal volume;

P_plat = plateau pressure;

PEEP = positive end-expiratory pressure.

P_plat is measured at the end of inhalation and prior to exhalation by using an inspiratory hold maneuver. During this maneuver, airflow is transiently (~0.5 sec) discontinued, which eliminates the effects of airway resistance. P_plat is never bigger than PIP and is typically <10 cm H₂O lower than PIP when airway resistance is not elevated.

Dynamic compliance represents pulmonary compliance during periods of gas flow, such as during active inspiration. Dynamic compliance is always lesser than or equal to static lung compliance because PIP − PEEP is always greater than P_plat − PEEP. It can be calculated using the following equation,

${\displaystyle C_{dyn}={\frac {V_{T}}{\mathrm {PIP-PEEP} }}}$ 

where

C_dyn = Dynamic compliance;

V_T = tidal volume;

PIP = Peak inspiratory pressure (the maximum pressure during inspiration);

PEEP = Positive End Expiratory Pressure:

Alterations in airway resistance, lung compliance and chest wall compliance influence C_dyn.

The dimensions of compliance in respiratory physiology are inconsistent with the dimensions of compliance in physics-based applications. In physiology,

${\displaystyle [C_{\text{pulmonary}}]={\frac {[\Delta V]}{[\Delta P]}}={\frac {L^{3}}{ML^{-1}T^{-2}}}={\frac {L^{4}T^{2}}{M}},}$ 

whereas in newtonian physics, compliance is defined as the inverse of the elastic stiffness constant k,

${\displaystyle [C_{\text{physics}}]={\frac {1}{[k]}}={\frac {[\delta x]}{[F]}}={\frac {L}{MLT^{-2}}}={\frac {T^{2}}{M}}.}$ 

Pulmonary compliance is analogous to capacitance.

Lung compliance is an important measurement in respiratory physiology.^[2][3]

• Decreased pulmonary compliance may be associated with fibrosis.
• Increased pulmonary compliance may be associated with COPD and emphysema due to loss of alveolar and elastic tissue.

Pulmonary surfactant increases compliance by decreasing the surface tension of water. The internal surface of the alveolus is covered with a thin coat of fluid. The water in this fluid has a high surface tension, and provides a force that could collapse the alveolus. The presence of surfactant in this fluid breaks up the surface tension of water, making it less likely that the alveolus can collapse inward. If the alveolus were to collapse, a great force would be required to open it, meaning that compliance would decrease drastically. Lung volume at any given pressure during inhalation is less than the lung volume at any given pressure during exhalation, which is called hysteresis.^[4]

Low compliance indicates a stiff lung and means extra work is required to bring in a normal volume of air. This occurs as the lungs in this case become fibrotic, lose their distensibility and become stiffer.

In a highly compliant lung, as in emphysema, the elastic tissue is damaged by enzymes. These enzymes are secreted by leukocytes (white blood cells) in response to a variety of inhaled irritants, such as cigarette smoke. Patients with emphysema have a very high lung compliance due to the poor elastic recoil. They have extreme difficulty exhaling air. In this condition extra work is required to get air out of the lungs. In addition, patients often have difficulties inhaling air as well. This is due to the fact that a highly compliant lung results in many Atelectasis which makes inflation difficult.^{[further explanation needed]} Compliance also increases with increasing age.

Both peak inspiratory and plateau pressure increase when elastic resistance increases or when pulmonary compliance decreases (e.g. during abdominal insufflation, ascites, intrinsic lung disease, obesity, pulmonary edema, tension pneumothorax). On the other hand, only peak inspiratory pressure increases (plateau pressure unchanged) when airway resistance increases (e.g. airway compression, bronchospasm, mucous plug, kinked tube, secretions, foreign body).^[5]

Compliance decreases in the following cases:

• Supine position
• Laparoscopic surgical interventions
• Severe restrictive pathologies
• Chronic restrictive pathologies
• Hydrothorax
• Pneumothorax
• High standing of a diaphragm
• Acute asthma attacks, where increased compliance also occurs for an unclear reason^[6]