Integrin alpha 6

ITGA6
Identifiers
Aliases	ITGA6, CD49f, ITGA6B, VLA-6, integrin subunit alpha 6, JEB6
External IDs	OMIM: 147556; MGI: 96605; HomoloGene: 20091; GeneCards: ITGA6; OMA:ITGA6 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	172,506,459 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	71,688,760 bp
RNA expression pattern
	Top expressed in
	tibial nerve; ; sural nerve; ; spinal ganglia; ; trigeminal ganglion; ; epithelium of colon; ; Achilles tendon; ; rectum; ; pylorus; ; tendon of biceps brachii; ; duodenum;
	Top expressed in
	sciatic nerve; ; epithelium of stomach; ; secondary oocyte; ; atrium; ; epithelium of lens; ; left lung lobe; ; crypt of lieberkuhn of small intestine; ; endothelial cell of lymphatic vessel; ; pyloric antrum; ; left colon;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	metal ion binding; integrin binding; protein binding; laminin binding; neuregulin binding; protein-containing complex binding; insulin-like growth factor I binding; cadherin binding;
Cellular component	integral component of membrane; membrane; focal adhesion; basal part of cell; plasma membrane; hemidesmosome; basement membrane; cell surface; integrin complex; basal plasma membrane; basolateral plasma membrane; external side of plasma membrane; integrin alpha6-beta4 complex; filopodium;
Biological process	cellular response to extracellular stimulus; hemidesmosome assembly; renal system development; nail development; positive regulation of cell-cell adhesion; filopodium assembly; negative regulation of extrinsic apoptotic signaling pathway; extracellular matrix organization; odontogenesis of dentin-containing tooth; cell-substrate adhesion; positive regulation of GTPase activity; cell adhesion; cell adhesion mediated by integrin; brown fat cell differentiation; positive regulation of apoptotic process; cell-substrate junction assembly; integrin-mediated signaling pathway; positive regulation of phosphorylation; cell-matrix adhesion; digestive tract development; ectodermal cell differentiation; leukocyte migration; skin development; positive regulation of transcription by RNA polymerase II; amelogenesis; cellular response to organic cyclic compound; positive regulation of cell-substrate adhesion; positive regulation of cell migration; cell-cell adhesion; positive regulation of neuron projection development;
	Sources:Amigo / QuickGO
Orthologs
	3655
	16403
	ENSG00000091409
	ENSMUSG00000027111
	P23229
	Q61739
NM_000210; NM_001079818; NM_001316306; NM_001365529; NM_001365530;
	NM_001394928
	NM_001277970; NM_008397
	NP_000201; NP_001073286; NP_001303235; NP_001352458; NP_001352459
	NP_001264899; NP_032423; NP_001393187
	Wikidata
View/Edit Human	View/Edit Mouse

Integrin alpha-6 is a protein that in humans is encoded by the ITGA6 gene.

Function

The ITGA6 protein product is the integrin alpha chain alpha 6. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. For example, alpha 6 may combine with beta 4 in the integrin referred to as TSP180, or with beta 1 in the integrin VLA-6. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling. Two transcript variants encoding different isoforms have been found for this gene.^[5] Specific loss of this integrin chain in the intestinal epithelium, and thus of their hemidesmosomes, induces long-standing colitis and infiltrating adenocarcinomas.^[6]

Interactions

ITGA6 has been shown to interact with TSPAN4^[7] and GIPC1.^[8]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000091409 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000027111 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: ITGA6 integrin, alpha 6".
^ De Arcangelis A, Hamade H, Alpy F, Normand S, Bruyère E, Lefebvre O, et al. (October 2017). "Hemidesmosome integrity protects the colon against colitis and colorectal cancer". Gut. 66 (10): 1748–1760. doi:10.1136/gutjnl-2015-310847. PMC 5595104. PMID 27371534.
^ Tachibana I, Bodorova J, Berditchevski F, Zutter MM, Hemler ME (November 1997). "NAG-2, a novel transmembrane-4 superfamily (TM4SF) protein that complexes with integrins and other TM4SF proteins". The Journal of Biological Chemistry. 272 (46): 29181–9. doi:10.1074/jbc.272.46.29181. PMID 9360996.
^ Tani TT, Mercurio AM (September 2001). "PDZ interaction sites in integrin alpha subunits. T14853, TIP/GIPC binds to a type I recognition sequence in alpha 6A/alpha 5 and a novel sequence in alpha 6B". The Journal of Biological Chemistry. 276 (39): 36535–42. doi:10.1074/jbc.M105785200. PMID 11479315.

External links

CD49f+Antigen at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
ITGA6 Info with links in the Cell Migration Gateway Archived 11 December 2014 at the Wayback Machine

This membrane protein–related article is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000091409 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000027111 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] "Entrez Gene: ITGA6 integrin, alpha 6".

[pmid27371534-6] De Arcangelis A, Hamade H, Alpy F, Normand S, Bruyère E, Lefebvre O, et al. (October 2017). "Hemidesmosome integrity protects the colon against colitis and colorectal cancer". Gut. 66 (10): 1748–1760. doi:10.1136/gutjnl-2015-310847. PMC 5595104. PMID 27371534.

[pmid9360996-7] Tachibana I, Bodorova J, Berditchevski F, Zutter MM, Hemler ME (November 1997). "NAG-2, a novel transmembrane-4 superfamily (TM4SF) protein that complexes with integrins and other TM4SF proteins". The Journal of Biological Chemistry. 272 (46): 29181–9. doi:10.1074/jbc.272.46.29181. PMID 9360996.

[pmid11479315-8] Tani TT, Mercurio AM (September 2001). "PDZ interaction sites in integrin alpha subunits. T14853, TIP/GIPC binds to a type I recognition sequence in alpha 6A/alpha 5 and a novel sequence in alpha 6B". The Journal of Biological Chemistry. 276 (39): 36535–42. doi:10.1074/jbc.M105785200. PMID 11479315.

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Integrin alpha 6

Contents

Function

Interactions

See also

References

Further reading

External links