Talk:Choline

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The intro needs better sources for the claim "essential".

The HMDB is a company that earns money with analyzing metabolites. It claims choline "is now an essential vitamin" but does not give any sources. The company does profit from declaring insufficient metabolization and providing means to check the metabolization.

While the LPI does provide sources, it did not read them carefully it seems as the authors cite a review sponsored by the Egg Board and Beef Checkoff (Wallace TC 2018) to claim that vegetarians are at risk of deficiency. Blausonorisch (talk) 06:55, 31 October 2024 (UTC)[reply]

Thank you. I will work on sourcing. The objectivity and scholarship of LPI always worries me.--Smokefoot (talk) 16:07, 31 October 2024 (UTC)[reply]

There is no dispute in the medical or nutritional community currently that choline is essential. The best source to use here would be the National Institutes of Health [1] and USDA [2]. The old consensus was that choline was "conditionally essential" [3], [4], [5] but that is no longer the case. There is coverage of this on the nutrient article. Psychologist Guy (talk) 19:18, 31 October 2024 (UTC)[reply]

A good source to add to this article is this recent review on choline [6] Psychologist Guy (talk) 19:20, 31 October 2024 (UTC)[reply]

Regarding the source added to the lead co-written by Steven H. Zeisel [7], it received a grant from the Egg Nutrition Center (owned by the American Egg Board). If you look up Zeisel he has completed research for the American Egg Board [8], [9] for nearly two decades. Indeed, the Wallace source that Blausonorisch refers to found here [10] was co-written by Steven H. Zeisel. Their review paper was funded by the Egg Nutrition Center, and the Beef Checkoff, a contractor to the National Cattleman's Beef Association. Steven H. Zeisel is far from a neutral source. I would suggest removing his article, as the Wallace review that he co-authored was removed. Psychologist Guy (talk) 19:38, 31 October 2024 (UTC)[reply]

A search for "Zeisel" on this Choline Wikipedia article, he is cited 9 times in the references. Some of these sources are primary and fail WP:MEDRS. Having looked into this deeply, the best 3 sources describing choline are essential are: This scoping review for Nordic Nutrition Recommendations [11], this 2024 review [12] and the previously mentioned National Institutes of Health [13]. These 3 sources should be added to the article as they contain a wealth of information. Psychologist Guy (talk) 20:01, 31 October 2024 (UTC)[reply]

Following WP:WFTWA, the LPI/Oregon State University review is a complete, easy-to-read, well-sourced reference authored by academic nutritional biochemists. I don't agree that Lehninger - a rigorous textbook for grad students - provides a better source for the general user. The Nordic and Springer sources suggested by Psychologist Guy are good, but not as readable or as educational for a casual reader as the LPI or NIH-ODS. Zefr (talk) 22:15, 31 October 2024 (UTC)[reply]