PKIG

PKIG
Identifiers
Aliases	PKIG, PKI-gamma, protein kinase (cAMP-dependent, catalytic) inhibitor gamma, cAMP-dependent protein kinase inhibitor gamma
External IDs	OMIM: 604932; MGI: 1343086; HomoloGene: 5133; GeneCards: PKIG; OMA:PKIG - orthologs
Gene location (Human)
Chr.	Chromosome 20 (human)
End	44,624,247 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	163,568,078 bp
RNA expression pattern
	Top expressed in
	right coronary artery; ; right ventricle; ; apex of heart; ; left coronary artery; ; right auricle; ; left ventricle; ; myocardium; ; vena cava; ; gastric mucosa; ; cardiac muscle tissue of right atrium;
	Top expressed in
	otic placode; ; saccule; ; aortic valve; ; endocardial cushion; ; atrioventricular valve; ; ascending aorta; ; renal corpuscle; ; otic vesicle; ; Paneth cell; ; right ventricle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein kinase inhibitor activity; cAMP-dependent protein kinase inhibitor activity;
Cellular component	cytoplasm; nucleus;
Biological process	negative regulation of transcription by RNA polymerase II; negative regulation of cAMP-dependent protein kinase activity; signal transduction; negative regulation of protein kinase activity; negative regulation of protein import into nucleus;
	Sources:Amigo / QuickGO
Orthologs
	11142
	18769
	ENSG00000168734
	ENSMUSG00000035268
	Q9Y2B9
	O70139
	NM_181805; NM_001281444; NM_001281445; NM_007066; NM_181804
NM_001039390; NM_001039391; NM_001164053; NM_001164055; NM_001277096;
	NM_011106
	NP_001268373; NP_001268374; NP_008997; NP_861520; NP_861521
NP_001034479; NP_001034480; NP_001157525; NP_001157527; NP_001264025;
	NP_035236
	Wikidata
View/Edit Human	View/Edit Mouse

cAMP-dependent protein kinase inhibitor gamma is a protein that in humans is encoded by the PKIG gene.^[5]^[6]

The protein encoded by this gene is a member of the cAMP-dependent protein kinase (PKA) inhibitor family. Studies of a similar protein in mice suggest that this protein acts as a potent competitive PKA inhibitor, and is a predominant form of PKA inhibitors in various tissues. Three alternatively spliced transcript variants encoding the same protein have been reported.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000168734 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000035268 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Zheng L, Yu L, Tu Q, Zhang M, He H, Chen W, Gao J, Yu J, Wu Q, Zhao S (Jan 2001). "Cloning and mapping of human PKIB and PKIG, and comparison of tissue expression patterns of three members of the protein kinase inhibitor family, including PKIA". Biochem J. 349 (Pt 2): 403–7. doi:10.1042/0264-6021:3490403. PMC 1221161. PMID 10880337.
^ ^a ^b "Entrez Gene: PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma".

Collins SP, Uhler MD (1997). "Characterization of PKIgamma, a novel isoform of the protein kinase inhibitor of cAMP-dependent protein kinase". J. Biol. Chem. 272 (29): 18169–78. doi:10.1074/jbc.272.29.18169. PMID 9218452.
Fossey SC, Mychaleckyj JC, Pendleton JK, et al. (2001). "A high-resolution 6.0-megabase transcript map of the type 2 diabetes susceptibility region on human chromosome 20". Genomics. 76 (1–3): 45–57. doi:10.1006/geno.2001.6584. PMID 11549316.
Lum H, Hao Z, Gayle D, et al. (2002). "Vascular endothelial cells express isoforms of protein kinase A inhibitor". Am. J. Physiol., Cell Physiol. 282 (1): C59–66. doi:10.1152/ajpcell.00256.2001. PMID 11742798.
Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. Bibcode:2001Natur.414..865D. doi:10.1038/414865a. PMID 11780052.
Yu J, Yu L, Chen Z, et al. (2002). "Protein inhibitor of neuronal nitric oxide synthase interacts with protein kinase A inhibitors". Brain Res. Mol. Brain Res. 99 (2): 145–9. doi:10.1016/S0169-328X(02)00104-3. PMID 11978406.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Zhao L, Yang S, Zhou GQ, et al. (2006). "Downregulation of cAMP-dependent protein kinase inhibitor gamma is required for BMP-2-induced osteoblastic differentiation". Int. J. Biochem. Cell Biol. 38 (12): 2064–73. doi:10.1016/j.biocel.2006.05.015. PMID 16870489.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

This article on a gene on human chromosome 20 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000168734 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000035268 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10880337-5] Zheng L, Yu L, Tu Q, Zhang M, He H, Chen W, Gao J, Yu J, Wu Q, Zhao S (Jan 2001). "Cloning and mapping of human PKIB and PKIG, and comparison of tissue expression patterns of three members of the protein kinase inhibitor family, including PKIA". Biochem J. 349 (Pt 2): 403–7. doi:10.1042/0264-6021:3490403. PMC 1221161. PMID 10880337.

[entrez-6] "Entrez Gene: PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma".

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References

Further reading