P4HA2: Difference between revisions

{{Orphan|date=October 2015}}

{{PBB|geneid=8974}}

'''Prolyl 4-hydroxylase subunit alpha-2''' is an [[enzyme]] that in humans is encoded by the ''P4HA2'' [[gene]].<ref name="pmid9211872">{{cite journal | author = Annunen P, Helaakoski T, Myllyharju J, Veijola J, Pihlajaniemi T, Kivirikko KI | title = Cloning of the human prolyl 4-hydroxylase alpha subunit isoform alpha(II) and characterization of the type II enzyme tetramer. The alpha(I) and alpha(II) subunits do not form a mixed alpha(I)alpha(II)beta2 tetramer | journal = J Biol Chem | volume = 272 | issue = 28 | pages = 17342–8 |date=Aug 1997 | pmid = 9211872 | pmc = | doi =10.1074/jbc.272.28.17342 }}</ref><ref name="pmid9149945">{{cite journal | author = Frazer KA, Ueda Y, Zhu Y, Gifford VR, Garofalo MR, Mohandas N, Martin CH, Palazzolo MJ, Cheng JF, Rubin EM | title = Computational and biological analysis of 680 kb of DNA sequence from the human 5q31 cytokine gene cluster region | journal = Genome Res | volume = 7 | issue = 5 | pages = 495–512 |date=Aug 1997 | pmid = 9149945 | pmc = | doi = 10.1101/gr.7.5.495}}</ref><ref name="entrez"/>

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{{PBB_Summary

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| summary_text = This gene encodes a component of prolyl 4-hydroxylase, a key enzyme in collagen synthesis composed of two identical alpha subunits and two beta subunits. The encoded protein is one of several different types of alpha subunits and provides the major part of the catalytic site of the active enzyme. In collagen and related proteins, prolyl 4-hydroxylase catalyzes the formation of 4-hydroxyproline that is essential to the proper three-dimensional folding of newly synthesized procollagen chains. Alternatively spliced transcript variants encoding different isoforms have been described.<ref name="entrez">{{cite web | title = Entrez Gene: P4HA2 procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha polypeptide II| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8974| accessdate = }}</ref>

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{{PBB_Further_reading

| citations =

*{{cite journal |vauthors=Helaakoski T, Annunen P, Vuori K, etal |title=Cloning, baculovirus expression, and characterization of a second mouse prolyl 4-hydroxylase alpha-subunit isoform: formation of an alpha 2 beta 2 tetramer with the protein disulfide-isomerase/beta subunit |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=92 |issue= 10 |pages= 4427–31 |year= 1995 |pmid= 7753822 |doi=10.1073/pnas.92.10.4427 | pmc=41957 }}

*{{cite journal |vauthors=Nokelainen M, Nissi R, Kukkola L, etal |title=Characterization of the human and mouse genes for the alpha subunit of type II prolyl 4-hydroxylase. Identification of a previously unknown alternatively spliced exon and its expression in various tissues |journal=Eur. J. Biochem. |volume=268 |issue= 20 |pages= 5300–9 |year= 2001 |pmid= 11606192 |doi=10.1046/j.0014-2956.2001.02464.x }}

*{{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}

*{{cite journal |vauthors=Hieta R, Kukkola L, Permi P, etal |title=The peptide-substrate-binding domain of human collagen prolyl 4-hydroxylases. Backbone assignments, secondary structure, and binding of proline-rich peptides |journal=J. Biol. Chem. |volume=278 |issue= 37 |pages= 34966–74 |year= 2003 |pmid= 12824157 |doi= 10.1074/jbc.M303624200 }}

*{{cite journal | author=Kukkola L, Hieta R, Kivirikko KI, Myllyharju J |title=Identification and characterization of a third human, rat, and mouse collagen prolyl 4-hydroxylase isoenzyme |journal=J. Biol. Chem. |volume=278 |issue= 48 |pages= 47685–93 |year= 2004 |pmid= 14500733 |doi= 10.1074/jbc.M306806200 }}

*{{cite journal | author=Koivunen P, Hirsilä M, Kivirikko KI, Myllyharju J |title=The length of peptide substrates has a marked effect on hydroxylation by the hypoxia-inducible factor prolyl 4-hydroxylases |journal=J. Biol. Chem. |volume=281 |issue= 39 |pages= 28712–20 |year= 2006 |pmid= 16885164 |doi= 10.1074/jbc.M604628200 }}

*{{cite journal | author=Teodoro JG, Parker AE, Zhu X, Green MR |title=p53-mediated inhibition of angiogenesis through up-regulation of a collagen prolyl hydroxylase |journal=Science |volume=313 |issue= 5789 |pages= 968–71 |year= 2006 |pmid= 16917063 |doi= 10.1126/science.1126391 }}

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