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{{Infobox_gene}}
{{Infobox_gene}}


'''Prolyl 4-hydroxylase subunit alpha-2''' is an [[enzyme]] that in humans is encoded by the ''P4HA2'' [[gene]].<ref name="pmid9211872">{{cite journal | vauthors = Annunen P, Helaakoski T, Myllyharju J, Veijola J, Pihlajaniemi T, Kivirikko KI | title = Cloning of the human prolyl 4-hydroxylase alpha subunit isoform alpha(II) and characterization of the type II enzyme tetramer. The alpha(I) and alpha(II) subunits do not form a mixed alpha(I)alpha(II)beta2 tetramer | journal = J Biol Chem | volume = 272 | issue = 28 | pages = 17342–8 |date=Aug 1997 | pmid = 9211872 | doi =10.1074/jbc.272.28.17342 | doi-access = free }}</ref><ref name="pmid9149945">{{cite journal | vauthors = Frazer KA, Ueda Y, Zhu Y, Gifford VR, Garofalo MR, Mohandas N, Martin CH, Palazzolo MJ, Cheng JF, Rubin EM | title = Computational and biological analysis of 680 kb of DNA sequence from the human 5q31 cytokine gene cluster region | journal = Genome Res | volume = 7 | issue = 5 | pages = 495–512 |date=Aug 1997 | pmid = 9149945 | doi = 10.1101/gr.7.5.495| doi-access = free }}</ref><ref name="entrez"/>
'''Prolyl 4-hydroxylase subunit alpha-2''' is an [[enzyme]] that in humans is encoded by the ''P4HA2'' [[gene]].<ref name="pmid9211872">{{cite journal | vauthors = Annunen P, Helaakoski T, Myllyharju J, Veijola J, Pihlajaniemi T, Kivirikko KI | title = Cloning of the human prolyl 4-hydroxylase alpha subunit isoform alpha(II) and characterization of the type II enzyme tetramer. The alpha(I) and alpha(II) subunits do not form a mixed alpha(I)alpha(II)beta2 tetramer | journal = J Biol Chem | volume = 272 | issue = 28 | pages = 17342–8 |date=Aug 1997 | pmid = 9211872 | pmc = | doi =10.1074/jbc.272.28.17342 | doi-access = free }}</ref><ref name="pmid9149945">{{cite journal | vauthors = Frazer KA, Ueda Y, Zhu Y, Gifford VR, Garofalo MR, Mohandas N, Martin CH, Palazzolo MJ, Cheng JF, Rubin EM | title = Computational and biological analysis of 680 kb of DNA sequence from the human 5q31 cytokine gene cluster region | journal = Genome Res | volume = 7 | issue = 5 | pages = 495–512 |date=Aug 1997 | pmid = 9149945 | pmc = | doi = 10.1101/gr.7.5.495| doi-access = free }}</ref><ref name="entrez"/>


This gene encodes a component of [[prolyl 4-hydroxylase]], a key enzyme in [[collagen]] synthesis composed of two identical alpha subunits and two beta subunits. The encoded protein is one of several different types of alpha subunits and provides the major part of the catalytic site of the active enzyme. In collagen and related proteins, prolyl 4-hydroxylase catalyzes the formation of [[4-hydroxyproline]] that is essential to the proper three-dimensional folding of newly synthesized [[procollagen]] chains. Alternatively spliced transcript variants encoding different [[isoforms]] have been described.<ref name="entrez">{{cite web | title = Entrez Gene: P4HA2 procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha polypeptide II| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8974}}</ref>
This gene encodes a component of [[prolyl 4-hydroxylase]], a key enzyme in [[collagen]] synthesis composed of two identical alpha subunits and two beta subunits. The encoded protein is one of several different types of alpha subunits and provides the major part of the catalytic site of the active enzyme. In collagen and related proteins, prolyl 4-hydroxylase catalyzes the formation of [[4-hydroxyproline]] that is essential to the proper three-dimensional folding of newly synthesized [[procollagen]] chains. Alternatively spliced transcript variants encoding different [[isoforms]] have been described.<ref name="entrez">{{cite web | title = Entrez Gene: P4HA2 procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha polypeptide II| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8974| accessdate = }}</ref>


==References==
==References==
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