Chronic neutrophilic leukemia: Difference between revisions
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Zittoun R, Rea D, Ngoc LH, Ramond S. "Chronic neutrophilic leukemia. A study of four cases." '''Ann Hematol.''' 1994 Feb;68(2):55-60. '''PMID''': 8148416</ref> |
Zittoun R, Rea D, Ngoc LH, Ramond S. "Chronic neutrophilic leukemia. A study of four cases." '''Ann Hematol.''' 1994 Feb;68(2):55-60. '''PMID''': 8148416</ref> |
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==Clinical Features== |
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===Clinical Presentation |
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The most common clincal finding is hepatosplenomegaly, Pruritus, gout, and mucocutaneous bleeding are occasionally seen.<ref name="zit1"><ref name="you1"> |
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===Laboratory Findings=== |
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Peripheral blood neutrophilia (> 25 x 10<sup>9</sup>/L) with myeloid precursors (promyelocytes, myelocytes, metamyelocytes) comprising less than 5%.<ref name="zit1"><ref name="you1"> |
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===Sites of Involvement=== |
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Peripheral [[blood]], [[bone marrow]], [[spleen]], and [[liver]] are most common, but any organ or tissue can be infiltrated by [[neutrophils]].<ref name="zit1"><ref name="you1"> |
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==References== |
==References== |
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Revision as of 16:12, 19 April 2007
Chronic neutrophilic leukemia (CNL) is a rare myeloproliferative disorder that features a persistent neutrophilia in peripheral blood, myeloid hyperplasia in bone marrow, hepatosplenomegaly, and the absence of the Philadelphia chromosome or a BCR/ABL fusion gene.[1]
Synonyms
None[1]
ICD-O Code
9963/3[1]
Epidemiology
This is a rare disease, with less than 100 cases reported. Of these cases, an equal male:female ratio was observed,[2] with cases typically seen in older adults.[3]
Clinical Features
===Clinical Presentation The most common clincal finding is hepatosplenomegaly, Pruritus, gout, and mucocutaneous bleeding are occasionally seen.<ref name="zit1"><ref name="you1">
Laboratory Findings
Peripheral blood neutrophilia (> 25 x 109/L) with myeloid precursors (promyelocytes, myelocytes, metamyelocytes) comprising less than 5%.<ref name="zit1"><ref name="you1">
Sites of Involvement
Peripheral blood, bone marrow, spleen, and liver are most common, but any organ or tissue can be infiltrated by neutrophils.<ref name="zit1"><ref name="you1">
References
- ^ a b c [1] Jaffe E.S., Harris N.L., Stein H., Vardiman J.W. (eds): World Health Organization Classification of Tumors. Pathology and Genetics of Tumours of Haemopoietic and Lymphoid Tissues. IARC Press: Lyon 2001
- ^ [2] You W, Weisbrot IM. "Chronic neutrophilic leukemia. Report of two cases and review of the literature." Am J Clin Pathol. 1979 Aug;72(2):233-42. PMID: 289288
- ^ [3] Zittoun R, Rea D, Ngoc LH, Ramond S. "Chronic neutrophilic leukemia. A study of four cases." Ann Hematol. 1994 Feb;68(2):55-60. PMID: 8148416