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A role for melanin-concentrating hormone in the central regulation of feeding behaviour

Nature volume 380, pages 243–247 (1996)Cite this article

Abstract

THE hypothalamus plays a central role in the integrated regulation of energy homeostasis and body weight, and a number of hypothalamic neuropeptides, such as neuropeptide Y (ref. 1), galanin2, CRH (ref. 3), and GLP-1 (ref. 4), have been implicated in the mediation of these effects. To discover new hypothalamic peptides involved in the regulation of body weight, we used differential display polymerase chain reaction5 to identify messenger RNAs that are differentially expressed in the hypothalamus of ob/+ compared with ob/ob C57B1/6J mice. We show here that one mRNA that is overexpressed in the hypothalamus of ob/ob mice encodes the neuropeptide melanin-concentrating hormone (MCH). Fasting further increased expression of MCH mRNA in both normal and obese animals. Neurons containing MCH are located in the zona incerta and in the lateral hypothalamus. These areas are involved in regulation of ingestive behaviour, but the role of MCH in mammalian physiology is unknown. To determine whether MCH is involved in the regulation of feeding, we injected MCH into the lateral ventricles of rats and found that their food consumption increased. These findings suggest that MCH participates in the hypothalamic regulation of body weight.

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References

  1. Stanley, B. G., Anderson, K. C., Grayson, M. H. & Leibowitz, S. F. Physiol. Behav. 46, 173–177 (1989).

    Article  CAS  Google Scholar 

  2. Kyrkouli, S. E., Stanley, B. G. & Leibowitz, S. F. Eur. J. Pharmacol. 122, 159–160 (1986).

    Article  CAS  Google Scholar 

  3. Arase, K., York, D. A., Shimizu, H., Shargill, N. & Bray, G. A. Am. J. Physiol. 255, E255–259 (1988).

    CAS  PubMed  Google Scholar 

  4. Turton, M. D. et al. Nature 379, 69–72 (1996).

    Article  ADS  CAS  Google Scholar 

  5. Liang, P. & Pardee, A. B. Science 257, 967–971 (1992).

    Article  ADS  CAS  Google Scholar 

  6. Nahon, J. L., Presse, F., Breton, C., Herview, G. & Schorpp, M. Ann. N.Y. Acad. Sci. 680, 111–129 (1993).

    Article  ADS  CAS  Google Scholar 

  7. Breton, C., Presse, F., Hervieu, G. & Nahon, J. L. Molec. cell. Neurosci. 4, 271–284 (1993).

    Article  CAS  Google Scholar 

  8. Tempel, D. L. & Leibowitz, S. F. Brain Res. Bull. 25, 821–825 (1990).

    Article  CAS  Google Scholar 

  9. Kawauchi, H., Kawazoe, M., Tsubplawa, M., Kishida, M. & Baker, B. I. Nature 305, 423–432 (1983).

    Article  Google Scholar 

  10. Kawauchi, H., Naito, N. & Ono, M. Ann. N.Y. Acad. Sci. 680, 64–77 (1993).

    Article  ADS  CAS  Google Scholar 

  11. Skofitsch, G., Jacobowitz, D. M. & Zamir, N. Brain Res. Bull. 15, 635–639 (1985).

    Article  CAS  Google Scholar 

  12. Zamir, N., Skofitsch, G., Bannon, M. J. & Jacobowitz, D. M. Proc. natn. Acad. Sci. U.S.A. 83, 1528–1531 (1986).

    Article  ADS  CAS  Google Scholar 

  13. Naito, N., Kawazoe, I., Nakai, Y. & Kawauchi, H. Cell Tissue Res. 253, 291–295 (1988).

    Article  CAS  Google Scholar 

  14. Thompson, R. C. & Watson, S. J. DNA Cell Biol. 9, 637–645 (1990).

    Article  CAS  Google Scholar 

  15. Bittencourt, J. C. et al. J. comp. Neurol. 319, 218–245 (1992).

    Article  CAS  Google Scholar 

  16. Nahon, J. L., Presse, F., Bittencourt, J. C., Sawchenko, P. E. & Vale, W. Endocrinology 125, 2056–2065 (1989).

    Article  CAS  Google Scholar 

  17. Parkes, D. G. & Vale, W. Endocrinology 131, 1826–1831 (1992).

    Article  CAS  Google Scholar 

  18. Risold, P. Y., Fellmann, D., Rivier, J., Vale, W. & Bugnon, C. Neurosci. Lett. 136, 145–149 (1992).

    Article  CAS  Google Scholar 

  19. Oomura, Y. New Physiol. Sci. 2, 199–203 (1987).

    CAS  Google Scholar 

  20. Cechetto, D. F. & Saper, C. B. J. comp. Neurol. 272, 579–604 (1988).

    Article  CAS  Google Scholar 

  21. Rance, T. & Baker, B. I. Gen. comp. Endocrin. 37, 64–73 (1979).

    Article  CAS  Google Scholar 

  22. Matsunaga, T. O., Hruby, V. I., Lebl, M., De Lauro Castrucci, A. M. & Hadley, M. E. Peptides 10, 773–778 (1989).

    Article  CAS  Google Scholar 

  23. Cone, R. D. et al. Ann. N.Y. Acad. Sci. 80, 342–363 (1993).

    Article  ADS  Google Scholar 

  24. Bultman, S. J., Michaud, E. J. & Woychik, R. P. Cell 75, 1195–1204 (1992).

    Article  Google Scholar 

  25. Klebrig, M. L., Wilkinson, J. E., Geisler, J. G. & Woychik, R. P. Proc. natn. Acad. Sci. U.S.A. 92, 4728–4732 (1995).

    Article  ADS  Google Scholar 

  26. Lu, D. et al. Nature 371, 799–803 (1994).

    Article  ADS  CAS  Google Scholar 

  27. Zhang, Y. et al. Nature 372, 425–432 (1994).

    Article  ADS  CAS  Google Scholar 

  28. Pelleymounter, M. A. et al. Science 269, 540–543 (1995).

    Article  ADS  CAS  Google Scholar 

  29. Jakubowski, M. & Roberts, R. L. J. Neuroendocrin. Appendix 2 (1991).

  30. Sanacora, G., Kershaw, M., Finkelstein, J. A. & White, J. D. Endocrinology 127, 730–736 (1990).

    Article  CAS  Google Scholar 

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Author notes

  1. Steen Gammeltoft

    Present address: Department of Clinical Chemistry, Glostrup Hospital, University of Copenhagen Medical chool, Dk2600, Glostrup, Denmark

Authors and Affiliations

  1. Research Laboratory, Joslin Diabetes Center, and Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts, 02215, USA

    Daqing Qu, Megan Piper & Eleftheria Maratos-Flier

  2. Department of Medicine, Division of Endocrinology, Beth Israel Hospital, Boston, Massachusetts, 02215, USA

    David S. Ludwig

  3. Department of Neurobiology, Amgen Inc., 1840 DeHavilland Drive, Thousand Oaks, California, 91320, USA

    Mary Ann Pelleymounter & Mary Jane Cullen

  4. Department of Psychology, Tufts University, Medford, Massachusetts, 2155, USA

    Wendy Foulds Mathes, Jeanne Przypek & Robin Kanarek

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  1. Daqing Qu
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Qu, D., Ludwig, D., Gammeltoft, S. et al. A role for melanin-concentrating hormone in the central regulation of feeding behaviour. Nature 380, 243–247 (1996). https://doi.org/10.1038/380243a0

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