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Studies of experimental rhinovirus type 2 infections in polar isolation and in England

Published online by Cambridge University Press:  15 May 2009

M. J. Holmes ,
Sylvia E. Reed ,
E. J. Stott  and
D. A. J. Tyrrell
M. J. Holmes
Affiliation:
British Antarctic Survey
Sylvia E. Reed
Affiliation:
Medical Research Council Common Cold Unit, Harvard Hospital, Salisbury, SP2 8BW, Wilts.
E. J. Stott
Affiliation:
Institute for Research on Animal Diseases, Compton, RG16 0NN, Berks.
D. A. J. Tyrrell
Affiliation:
Clinical Research Centre, Harrow, HA1 3UJ, Middlesex
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After five months of total isolation a wintering party of seventeen British Antarctic Survey (BAS) personnel was inoculated under double blind conditions with placebo, or rhinovirus type 2 which had been propagated in tissue culture. The clinical and virological responses of these subjects were compared with those of volunteers in England who received a similar dose of the same strain. The virus used was apparently partly attenuated for man; at the dosage used its effects in England were similar to a smaller dose of an unattenuated strain, but in the Antarctic it caused relatively severe infections. Both the symptoms and the laboratory evidence of virus infection appeared to be more pronounced in the BAS subjects than in the volunteers in England who received the same challenge. In the former group the infection readily spread to those who were originally given placebo. In the BAS subjects serum antibody titres were well maintained during the isolation period but a significant fall in nasal immunoglobulin concentration was recorded during the 5 months of isolation after the virus challenge. Possible mechanisms for the increased sensitivity to rhinovirus of subjects who have been totally isolated in a small closed community are discussed.

Type
Research Article
Information
Journal of Hygiene , Volume 76 , Issue 3 , June 1976 , pp. 379 - 393
Copyright
Copyright © Cambridge University Press 1976

References

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