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Petri net based description and modeling of metabolic pathway

Published: 16 July 2007 Publication History

Abstract

System Biology is a rapidly developing discipline which utilizes mathematical and computer science techniques to analyze and interpret biological models. Furthermore advances in analytical and computational technologies are driving the transition to a systems biology that deals with the integrated behavior of biomolecular and metabolic networks. In this paper we use Petri nets to model and simulate the process of carbohydrate metabolic pathways in general and the pentose phosphate pathway in particular. Modeling and simulation of carbohydrate metabolism and pentose phosphate pathway will improve the understanding of the structure and the dynamics of these pathways considerably. Petri nets have been proposed as an effective formalism for Systems Biology and modeling of metabolic pathways.

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David, R., Alla, H., 2005. Discrete, Continuous, and Hybrid Petri Nets, Springer Verlag, Heidelberg.
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Hofestädt, R.: A Petri Net Application of Metabolic Processes: Journal of System Analysis, Modelling and Simulation. 1994, 16; pp. 113--122
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Hucka, M., Finney, A., Sauro, H., et al.: Systems Biology Markup Language (SBML) Level 1, Version 1 (Final), 2 March 2001
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Martini, Frederic H., 2006. Fundamentals of Anatomy and Physiology (7th edition). Pearson Education, Inc., USA.
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Murata, T,. 1989 Petri nets: Properties, analysis and applications. Proc. of the IEEE 77, 541--580.
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Reddy, V. N., Mavrovouniotis, M. L. and Liebman, M. N.: Petri Net Representation in Metabolic Pathways. In: Proceedings of the First International Conference on Intelligent Systems for Molecular Biology, AAAI Press, Menlo Park, 1993; pp. 328--336
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Petri, C. A. (1962) PhD Thesis, Institut für Instrumentelle Mathematik, Bonn
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WWW http://www.informatik.uni-hamburg.de/TGI/PetriNets/

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Published In

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SCSC '07: Proceedings of the 2007 Summer Computer Simulation Conference
July 2007
1363 pages
ISBN:1565553160

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  • SCS: Society for Modeling and Simulation International

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Society for Computer Simulation International

San Diego, CA, United States

Publication History

Published: 16 July 2007

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Author Tags

  1. Petri net
  2. modeling
  3. pentose phosphate pathway
  4. simulation

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SCSC07
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  • SCS
SCSC07: 2007 Summer Computer Simulation Conference
July 16 - 19, 2007
California, San Diego

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