Human glutaminyl cyclase (hQC) inhibitors have great potential to be used as anti- Alzheimer's disease (AD) agents by reducing the toxic pyroform of β-amyloid in the brains of AD patients. The four-dimensional quantitative structure activity ...

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• Established a 4D-QSAR model for N-substituted urea/thioureas with good predictive ability.
• Designed and evaluated new N-substituted urea/thioureas as potential hQC inhibitors.
• Confirmed stability and interaction patterns with hQC ...

Summary: Investigation of transcription factors (TFs) and their downstream regulated genes (targets) is a significant issue in post-genome era, which can provide a brand new vision for some vital biological process. However, information of TFs and their ...

Finding all gene structures is a crucial step in obtaining valuable information from genomic sequences. It is still a challenging problem, especially for vertebrate genomes, such as the human genome. Expressed Sequence Tags (ESTs) provide a tremendous ...