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- research-articleNovember 2024
Exploring the binding dynamics of covalent inhibitors within active site of PLpro in SARS-CoV-2
Computational Biology and Chemistry (COBC), Volume 112, Issue Chttps://doi.org/10.1016/j.compbiolchem.2024.108132AbstractIn the global fight against the COVID-19 pandemic caused by the highly transmissible SARS-CoV-2 virus, the search for potent medications is paramount. With a focused investigation on the SARS-CoV-2 papain-like protease (PLpro) as a promising ...
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Highlights- Targeting the SARS-CoV-2 PLpro could be key for COVID-19 treatment due to its crucial role in viral replication and immune response modulation.
- The PLpro catalytic site, particularly Cys111, is a promising target for covalent bonding, ...