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2 Results for: Author: Saini, Gurvinder Kaur
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- research-articleNovember 2024
Gliotoxin triggers cell death through multifaceted targeting of cancer-inducing genes in breast cancer therapy
Computational Biology and Chemistry (COBC), Volume 112, Issue Chttps://doi.org/10.1016/j.compbiolchem.2024.108170AbstractFungal secondary metabolites have a long history of contributing to pharmaceuticals, notably in the development of antibiotics and immunosuppressants. Harnessing their potent bioactivities, these compounds are now being explored for cancer ...
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Highlights- The fungal secondary metabolite, Gliotoxin has emerged as a potential candidate with promising anticancer properties.
- From the in-silico studies, MAPK1, NFKB1, HIF1A, TDP1, TRIM24, and CTSD were identified as the molecular targets of ...
- research-articleNovember 2024
Exploring potential molecular targets and therapeutic efficacy of beauvericin in triple-negative breast cancer cells
Computational Biology and Chemistry (COBC), Volume 112, Issue Chttps://doi.org/10.1016/j.compbiolchem.2024.108154AbstractTriple negative breast cancer (TNBC) presents a significant global health concern due to its aggressive nature, high mortality rate and limited treatment options, highlighting the urgent need for targeted therapies. Beauvericin, a bioactive ...
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Highlights- In silico study identified MRP1, HDAC1, HDAC2, LCK and SYK as possible molecular targets of beauvericin.
- Beauvericin reduced TNBC cell viability and induced oxidative stress mediated apoptosis.
- It halted cell cycle progression at ...