Introduction: E-health systems are increasingly important and widespread, but their selection and implementation are still frequently based on belief, rather than scientific evidence, and adverse effects are not systematically addressed. Progress is being made in promoting generic evaluation methodologies as a source of scientific evidence, but effort is now needed to consider methods for special situations. Method: Review of five evaluation contexts - national e-health plans, telemedicine, Health Informatics 3.0, usability and economics. Conclusion: Identification of requirements for approaches to be developed in these five settings.