Journal of the Serbian Chemical Society 2007 Volume 72, Issue 1, Pages: 5-11
https://doi.org/10.2298/JSC0701005Y
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Synthesis and antimycobacterial activity of novel heterocycles
Yar Shahar M. (Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Jamia Hamdard (Hamdard University), New Delhi)
Siddiqui Ahmad A. (Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Jamia Hamdard (Hamdard University), New Delhi)
Ali Ashraf M. (Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Jamia Hamdard (Hamdard University), New Delhi)
In the present investigation 4-hydroxy-3-methylacetophenone on condensation with various aromatic aldehydes in methanolic KOH solution yielded the corresponding chalcones (CI-CXI). These chalcones were further reacted with hydrazine hydrate in ethanol which led to the formation of pyrazoline derivatives (HI-HXI). The newly synthesized heterocyles were characterized on the basis of their chemical properties and spectroscopic data. All newly synthesized compounds were evaluated for their antimycobacterial activities against Mycobacterium tuberculosis H37Rv. .
Keywords: pyrazoline, antimycobacterial, mycobacterium tuberculosis