Abstract
A simple electrochemical method for estimating the antioxidant activity (AA) of flavonoids has been developed. The proposed method is based on a measurement of the half-wave potential (E1/2) of the first oxidation wave of flavonoids by using flow-through column electrolysis. At the same time, the lipid peroxidation (LPO) inhibiting effects of these flavonoids were determined. A quantitative structure–activity relationship was obtained to describe the AA of flavonoids: IC50(¼M) = 30.36 + 151.50E1/2 (V)–12.63log P (r = 0.852), where IC50 represents the concentration for 50% inhibition of LPO, and P represents the octanol/water partition coefficient. This method is expected to be useful for the quick screening of flavonoid antioxidants, and evaluating the AA of flavonoid-containing foods and medicinal plants.
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Yang, B., Kotani, A., Arai, K. et al. Estimation of the Antioxidant Activities of Flavonoids from Their Oxidation Potentials. ANAL. SCI. 17, 599–604 (2001). https://doi.org/10.2116/analsci.17.599
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DOI: https://doi.org/10.2116/analsci.17.599