Abstract

We developed second-generation (G2) optical-resolution photoacoustic microscopy (OR-PAM). Incorporation of a novel acoustic detection scheme improved upon the sensitivity of our first-generation (G1) system by $18.4\mathrm{dB}$, deepening the in vivo tissue penetration to $1.2\mathrm{mm}$ at $570\mathrm{nm}$. Moreover, translating the imaging head instead of the living object accelerated the scanning speed by a factor of 5, widening the field of view within the same acquisition time. Mouse ears, as well as mouse brains with intact craniums, were imaged in vivo in both total concentration and oxygen saturation of hemoglobin.

© 2011 Optical Society of America

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