A common architectural feature of the genome in many organisms is chromatin domains. A synthetic biology approach now builds chromatin domains from scratch and identifies some of the minimal components needed for their formation.
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Busby, T., Misteli, T. Building chromatin from the ground up. Nat Genet 56, 360–361 (2024). https://doi.org/10.1038/s41588-024-01666-1
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DOI: https://doi.org/10.1038/s41588-024-01666-1