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Concepts of tissue injury and cell death in inflammation: a historical perspective

Nature Reviews Immunology volume 14, pages 51–59 (2014)Cite this article

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An Erratum to this article was published on 24 January 2014

This article has been updated

Abstract

Emerging evidence indicates that the molecular mechanisms of cell death have regulatory roles in inflammation and that the molecular changes that are associated with different forms of cell death affect the course of inflammation in different ways. In this Timeline article, we discuss how our understanding of the mechanisms and functional roles of tissue injury and cell death in inflammation has evolved on the basis of almost two centuries of study. We describe how such ideas have led to our current models of cell death and inflammation, and we highlight the remaining gaps in our knowledge of the subject.

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Figure 1
Figure 2: Direct and indirect causes of cell death in inflammation.

Change history

  • 23 December 2013

    In figure 1 (Timeline) of the original article, the dates in the second part of the figure were missing. This has now been corrected online. Nature Reviews Immunology apologizes for this error.

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Acknowledgements

The authors thank O. Brenner, I. Cohen and A. Elson for advice on the manuscript. D.W. is the incumbent of the Joseph and Bessie Feinberg Professorial Chair at The Weizmann Institute of Science, Rehovot, Israel.

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Authors and Affiliations

  1. Department of Biological Chemistry, The Weizmann Institute of Science, Rehovot, 76100, Israel

    David Wallach & Andrew Kovalenko

  2. Department of Biotechnology, College of Biomedical and Health Science, Konkuk University, Chungju, 380–701, South Korea

    Tae-Bong Kang

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  1. David Wallach
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  2. Tae-Bong Kang
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Correspondence to David Wallach.

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Wallach, D., Kang, TB. & Kovalenko, A. Concepts of tissue injury and cell death in inflammation: a historical perspective. Nat Rev Immunol 14, 51–59 (2014). https://doi.org/10.1038/nri3561

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