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Decade in review—hepatocellular carcinoma

HCC—subtypes, stratification and sorafenib

Nature Reviews Gastroenterology & Hepatology volume 11, pages 645–647 (2014)Cite this article

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The past 10 years have represented a whirlwind of activity with regard to information on the risk factors, aetiopathogenesis, diagnosis and treatment of hepatocellular carcinoma. I will describe what I consider to be the major advances from both a tumour biology perspective and a clinical perspective over the past 10 years.

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Figure 1: Future strategies for HCC diagnosis and treatment.

References

  1. Tanabe, K. K. et al. Epidermal growth factor gene functional polymorphism and the risk of hepatocellular carcinoma in patients with cirrhosis. JAMA 299, 53–60 (2008).

    Article  CAS  Google Scholar 

  2. Nault, J. C. et al. High frequency of telomerase reverse-transcriptase promoter somatic mutations in hepatocellular carcinoma and preneoplastic lesions. Nat. Commun. 4, 2218 (2013).

    Article  Google Scholar 

  3. Hoshida, Y. et al. Gene expression in fixed tissues and outcome in hepatocellular carcinoma. N. Engl. J. Med. 359, 1995–2004 (2008).

    Article  CAS  Google Scholar 

  4. Nault, J. C. et al. A hepatocellular carcinoma 5-gene score associated with survival of patients after liver resection. Gastroenterology 145, 176–187 (2013).

    Article  CAS  Google Scholar 

  5. Govaere, O. et al. Keratin 19: a key role player in the invasion of human hepatocellular carcinomas. Gut 63, 674–685 (2014).

    Article  CAS  Google Scholar 

  6. Chen, C. J. et al. Risk of hepatocellular carcinoma across a biological gradient of serum hepatitis B virus DNA level. JAMA 295, 65–73 (2006).

    Article  CAS  Google Scholar 

  7. Forner, A. et al. Diagnosis of hepatic nodules 20 mm or smaller in cirrhosis: prospective validation of the noninvasive diagnostic criteria for hepatocellular carcinoma. Hepatology 47, 97–104 (2008).

    Article  Google Scholar 

  8. Memon, K. et al. Radiographic response to locoregional therapy in hepatocellular carcinoma predicts patient survival times. Gastroenterology 141, 526–535 (2011).

    Article  Google Scholar 

  9. Mazzaferro, V. et al. Predicting survival after liver transplantation in patients with hepatocellular carcinoma beyond the Milan criteria: a retrospective, exploratory analysis. Lancet Oncol. 10, 35–43 (2009).

    Article  Google Scholar 

  10. Llovet, J. M. et al. Sorafenib in advanced hepatocellular carcinoma. N. Engl. J. Med. 359, 378–390 (2008).

    Article  CAS  Google Scholar 

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Acknowledgements

This work was supported by National Institute of Health Grant DK59427 and the Mayo Clinic.

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  1. Division of Gastroenterology and Hepatology, Mayo College of Medicine, Mayo Clinic, 200 First Street SW, Rochester, 55905, MN, USA

    Gregory J. Gores

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  1. Gregory J. Gores
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Correspondence to Gregory J. Gores.

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The author declares no competing financial interests.

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Gores, G. HCC—subtypes, stratification and sorafenib. Nat Rev Gastroenterol Hepatol 11, 645–647 (2014). https://doi.org/10.1038/nrgastro.2014.157

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