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Putting immunoinformatics to the test

Nature Biotechnology volume 24, pages 791–792 (2006)Cite this article

A consensus epitope prediction approach identifies the epitopes responsible for 95% of the murine T-cell response to vaccinia virus.

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Figure 1: The traditional approach to epitope mapping the vaccinia genome would involve synthesizing almost 176,000 overlapping 8-mer, 9-mer and 10-mer peptides (gray).

Bob Crimi

References

  1. Moutaftsi, M. et al. Nat. Biotechnol. 24, 817–819 (2006).

    Article  CAS  Google Scholar 

  2. Santori, F.R., Brown, S.M. & Vukmanovic, S. Immunol. Rev. 190, 146–160 (2002).

    Article  CAS  Google Scholar 

  3. Inaba, H. et al. J. Clin. Endocrinol. Metab. 91, 2286–2294 (2006).

    Article  CAS  Google Scholar 

  4. Westritschnig, K. & Valenta, R. Curr. Opin. Allergy Clin. Immunol. 3, 495–500 (2003).

    Article  CAS  Google Scholar 

  5. Ely, L.K. et al. J. Immunol. 174, 5593–5601 (2005).

    Article  CAS  Google Scholar 

  6. Wu, Z. et al. Nat. Med. 10, 87–92 (2004).

    Article  CAS  Google Scholar 

  7. Mallone, R. & Nepom, G.T. Clin. Immunol. 110, 232–242 (2004).

    Article  CAS  Google Scholar 

  8. De Groot, A.S., Knopf, P.M. & Martin W. De-immunization of therapeutic proteins by T cell epitope modification. In State of the Art Analytical Methods for the Characterization of Biological Products and Assessment of Comparabilitiy. (ed. Mire Sluis, A.) Vol 122. pp 137–160 (Dev. Biol. Basel, Karger, 2005).

  9. Lazarski C.A. et al. Immunity 23, 29–40 (2005).

    Article  CAS  Google Scholar 

  10. pasquetto V. et al. J. Immunol. 175, 5504–5515 (2005).

    Article  CAS  Google Scholar 

  11. Kim, S.K. et al. J. Exp. Med. 201, 523–533 (2005).

    Article  CAS  Google Scholar 

  12. Nagayama Y. et al. J. Immunol. 173, 2167–2173 (2004).

    Article  CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. Brown Medical School, 70 Ship Street, Providence, 02903, Rhode Island, USA

    Leonard Moise & Anne S De Groot

  2. EpiVax, Inc., 146 Clifford Street, Providence, 02903, Rhode Island, USA

    Leonard Moise & Anne S De Groot

Authors
  1. Leonard Moise
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  2. Anne S De Groot
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Moise, L., De Groot, A. Putting immunoinformatics to the test. Nat Biotechnol 24, 791–792 (2006). https://doi.org/10.1038/nbt0706-791

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