Abstract
The clinical, angiographic, ultrastructural and immunohistochemical features of a bilateral and asymmetrical case of Coats' disease in a three year old girl are described. The left eye showed advanced disease and was enucleated. Pathological examination revealed an exudative vasculopathy with ultrastructural evidence of interendothelial cell separation and formation of fenestrations. An isolated vascular malformation was discovered in the right eye. This was successfully treated with Argon laser under general anaesthesia.
Article PDF
References
Manschot WA and de Bruijn WC : Coats' disease: definition and pathogenesis. Br. J. Ophthalmol. 1967, 51: 145–57.
Tarkkanen A and Laatikainen L : Coats' disease: clinical angiographic, histopathological findings and clinical management. Br. J. Ophthalmol. 1983, 67: 766–76.
Change M, McLean IW and Merritt JC : Coats' disease: a study of 62 histologically confirmed cases. J. Pediatric Ophthal. and Strab. 1984, 21 (5): 163–8.
Tripathi R and Ashton N : Electron microscopical study of Coats' disease. Brit. J. Ophthalmol. 1971, 55: 289–301.
Coats G : Forms of retinal disease with massive exudation. R. Lond. Ophthal. Hosp. 1907–1908, 17: 440–525.
Coats G : Ueber Retinitis exudativa (Retinitis haem-orrhagica externa). Graefe's Arch. Ophthalmol. 1912, 81: 275–327.
Ridley ME, Shields JA, Brown GC and Tasman W : Coats' disease. Evaluation of management. Ophthalmol. 1982, 89: 12, 1381–7.
Woods AC and Duke JR : Coats' disease: review of literature diagnostic criteria, clinical findings and plasma lipid studies. Br. J. Ophthalmol. 1963, 47: 385–410.
Egerer I, Tasman W and Tomer TL : Coats disease. Arch. Ophthalmol. 1974, 82: 109–112.
Deutsch TA, Rabb MF and Jampol LM : Spontaneous regression of retinal lesions in Coats' disease. Can. J. Ophthalmol. 1982, 17: 169–72.
Chisholm IA, Foulds WS and Christison D : Investigation and therapy of Coats' disease. Trans. Ophthalmol. Soc. UK 1974, 94: 335–41.
Theodossiadis GP : Some clinical, fluorescein angiographic and therapeutic aspects of Coats' disease. J. Pediat. Ophthalmol. and Strab. 1979, 16: 257–62.
Leber Th : Ueber eine durch Vorkommen multipler Miliar-aneurysmen charakterisierte Form von Retinal-degeneration. Graefe's Arch. Ophthalmol. 1912, 81: 1–14.
Reese ASB : Telangiectasis of the retina and Coats' disease. Am. J. Ophthalmol. 1956, 42: 1–8.
Morales GA : Coats' disease: natural history and result of treatment. Am. J. Ophthalmol. 1965, 60: 855–65.
L'Esperance FA : Coats' disease: In ophthalmic lasers; photocoagulation, photoradiation and surgery, 2nd edn, Mosby 1983, 210–216.
Ikui H, Kumano S and Inomata H : Histopathology of Coats' disease (report of a case). Folia. Ophthalmol. Jap. 1971, 22: 832–9.
Hada K : Clinical and pathological studies on Coats' disease. II. Clinical and histopathological observations. Acta Soc. Ophthalmol. Jap. 1973, 775: 438–59.
Yashimoto H : Ultrastructure of vessels in haemorrhagic area of human retina. Jap. J. Ophthalmol. 1976, 20: 233–42.
Kimura T, Matsuhashi H and Ishii A : Ultrastructural changes of pathological human retinal vessels showing abnormal permeability—endo-thelial fenestrations and atheromatous degeneration. Nippon Gonka. Gakkas. Zasshi. 1983, 87(11): 119–211.
Farkas T, Potts A and Boone, C : Some pathological and biochemical aspects of Coats' disease. Am. J. Ophthalmol. 1973, 75: 289–301.
Ishikawa T : Fine structure of subretinal fibrous tissue in Coats' disease. Jap. J. Ophthalmol. 1976, 20: 63–74.
Takei J : Origin of ghost cell in Coats' disease. Invest. Ophthalmol. Vis. Sci. 1976, 15: 677–81.
Ohba S, Yamada I, Miki T and Matsuyama M : A case of Coats' disease—Histopathological study. Folia. Ophthalmol. Jap. 1977, 28: 1013–7.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
McGettrick, P., Loeffler, K. Bilateral Coats' disease in an infant (a clinical, angiographic, light and electron microscopic study). Eye 1, 136–145 (1987). https://doi.org/10.1038/eye.1987.20
Issue Date:
DOI: https://doi.org/10.1038/eye.1987.20