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Cardiac excitation–contraction coupling

Nature volume 415, pages 198–205 (2002)Cite this article

Abstract

Of the ions involved in the intricate workings of the heart, calcium is considered perhaps the most important. It is crucial to the very process that enables the chambers of the heart to contract and relax, a process called excitation–contraction coupling. It is important to understand in quantitative detail exactly how calcium is moved around the various organelles of the myocyte in order to bring about excitation–contraction coupling if we are to understand the basic physiology of heart function. Furthermore, spatial microdomains within the cell are important in localizing the molecular players that orchestrate cardiac function.

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Figure 1: Ca2+ transport in ventricular myocytes.
Figure 2: Quantitative Ca2+ fluxes during excitation–contraction coupling.
Figure 3: Na+/Ca2+ exchange during an action potential.
Figure 4: Confocal images of Ca2+ sparks and waves.
Figure 5: Candidate mechanisms for activation of Ca2+ release from the sarcoplasmic reticulum.
Figure 6: β-Adrenergic receptor activation and phosphorylation targets relevant to excitation–contraction coupling.

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  1. Department of Physiology, Stritch School of Medicine, Loyola University Chicago, 2160 South First Avenue, Maywood, 60153, Illinois, USA

    Donald M. Bers

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Bers, D. Cardiac excitation–contraction coupling. Nature 415, 198–205 (2002). https://doi.org/10.1038/415198a

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