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Angiogenesis in cancer and other diseases

Nature volume 407, pages 249–257 (2000)Cite this article

Abstract

Pathological angiogenesis is a hallmark of cancer and various ischaemic and inflammatory diseases. Concentrated efforts in this area of research are leading to the discovery of a growing number of pro- and anti-angiogenic molecules, some of which are already in clinical trials. The complex interactions among these molecules and how they affect vascular structure and function in different environments are now beginning to be elucidated. This integrated understanding is leading to the development of a number of exciting and bold approaches to treat cancer and other diseases. But owing to several unanswered questions, caution is needed.

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Figure 1: Chaotic and mosaic vessels in tumours.
Figure 2: Role of hypoxia in tumour angiogenesis.

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Acknowledgements

We acknowledge the critical input of C. Mouta Carreira, B. Fenton, D. Fukumura, J. Samson, A. Kadambi, B. Stoll and E. diTomaso in manuscript preparation and L. L. Munn, M. Leunig and A. Vandenhoeck in figure preparation. This work was supported by grants from the NIH, NSF, DOD, ACS, the National Foundation for Cancer Research and the Whitaker Foundation (R.K.J.), and from the VIB, FWO, Biomed and the VLK (P.C.). Owing to space limitations we have cited review articles instead of original references; relevant material that could not be included in this review is available at http://steele.mgh.harvard.edu.

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  1. The Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology, KU Leuven, B-3000, Leuven, Belgium

    Peter Carmeliet

  2. Steele Laboratory for Tumor Biology Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, 02114 , Massachusetts, USA

    Rakesh K. Jain

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Carmeliet, P., Jain, R. Angiogenesis in cancer and other diseases. Nature 407, 249–257 (2000). https://doi.org/10.1038/35025220

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