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Selective stabilisation of developing synapses as a mechanism for the specification of neuronal networks

Nature volume 264, pages 705–712 (1976)Cite this article

Abstract

The specificity of synapses in the mammalian brain cannot possibly be accounted for by one-to-one biochemical matching. The alternative proposed in this article is that connections are genetically specified between classes of cells, but the final wiring pattern depends on the refinement of those collections by selective stabilisation during neuronal activity.

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  1. Institut Pasteur and College de France, Paris, France

    Jean-Pierre Changeux & Antoine Danchin

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Changeux, JP., Danchin, A. Selective stabilisation of developing synapses as a mechanism for the specification of neuronal networks. Nature 264, 705–712 (1976). https://doi.org/10.1038/264705a0

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