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Microfluidic Systems: Recent Advances in Chronic Disease Diagnosis and Their Therapeutic Management

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Abstract

Microfluidics has advanced the area of diagnostics during the past ten years by offering fresh approaches that weren’t achievable with traditional detection and treatment techniques. High-throughput operations can be carefully controlled by using microfluidics and are very cost-effective too. It has been accepted to be a quick and effective method for controlled medication delivery, biological sample preparation, and analysis. This new technology has made it possible to create a wide range of micro and nanocarriers for poorly soluble medications, which has many advantages over traditional drug delivery techniques. Furthermore, a targeted medication delivery system utilizing microfluidic technology can be developed to enhance the drug's local bioavailability. Over the years, extensive R&D in microfluidic technology has led to the creation of various advanced applications in both laboratory and consumer biotechnology. Miniaturized genetic and proteasome analyzers, cell culture and control platforms, biosensors, disease detection, optical imaging devices, diagnostic advanced drugs, drug delivery schemes, and innovative products are some of the advanced applications of the microfluidics system. Also, these are highly adaptable microfluidic tools for disease detection and organ modeling, as well as transduction devices used in biomedical applications to detect biological and chemical changes. Beyond the specialized difficulties in studying cell–cell interactions, microfluidics has several difficulties in biomedical applications, especially for diagnostic devices where minute interactions can lead to imprecise evaluations. Assay function can be significantly changed by the way plastics, adhesives, and other materials interact. Therefore, the foundation of microfluidic technology needs to be grounded in real-world uses that can be produced on a big scale and at a reasonable cost. Further, it is a very interdisciplinary field that requires the collaboration of professionals in fluidics, assay science, materials science, and instrumentation to provide devices with the proper and needed functionality. In this article, we have discussed the advanced disease diagnosis and their therapeutic management which will help to understand the current scenario in the field of microfluidics diagnosis and will fill knowledge about the ‘gap’ in the system.

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Data Availability

No data was used for the research described in the article.

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Acknowledgements

Authors are grateful to Dr. Shoor Vir Singh, Professor and Head, Department of Biotechnology at GLA University, Mathura for help and support during the present study.

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This review did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.

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  1. Swadha Pandey and Saurabh Gupta have equal contribution.

Authors and Affiliations

  1. Department of Biotechnology, GLA University, Mathura, Uttar Pradesh, 281406, India

    Swadha Pandey, Saurabh Gupta & Alok Bharadwaj

  2. Sapien Biosciences, Apollo Health City, Hyderabad, Telangana, 500096, India

    Amisha Rastogi

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  1. Swadha Pandey
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  2. Saurabh Gupta
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  3. Alok Bharadwaj
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Contributions

Saurabh G, AB contributed to the conceptualization, literature search, data collection, study design; Swadha G, AR contributed to critical review and preparation of the final version of the manuscript.

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Correspondence to Alok Bharadwaj or Amisha Rastogi.

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Pandey, S., Gupta, S., Bharadwaj, A. et al. Microfluidic Systems: Recent Advances in Chronic Disease Diagnosis and Their Therapeutic Management. Indian J Microbiol (2024). https://doi.org/10.1007/s12088-024-01296-5

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