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Radio-frequency lesioning in brain tissue with coagulation-dependent thermal conductivity: modelling, simulation and analysis of parameter influence and interaction

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Abstract

Radio-frequency brain lesioning is a method for reducing e.g. symptoms of movement disorders. A small electrode is used to thermally coagulate malfunctioning tissue. Influence on lesion size from thermal and electric conductivity of the tissue, microvascular perfusion and preset electrode temperature was investigated using a finite-element model. Perfusion was modelled as an increased thermal conductivity in non-coagulated tissue. The parameters were analysed using a 24-factorial design (n = 16) and quadratic regression analysis (n = 47). Increased thermal conductivity of the tissue increased lesion volume, while increased perfusion decreased it since coagulation creates a thermally insulating layer due to the cessation of blood perfusion. These effects were strengthened with increased preset temperature. The electric conductivity had negligible effect. Simulations were found realistic compared to in vivo experimental lesions.

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Acknowledgments

The authors would like to thank Prof. Eva Enqvist, Department of Mathematics, Linköping University, for her interest and valuable aid with the statistical design and analysis.

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Authors and Affiliations

  1. Department of Biomedical Engineering, Linköping University, 581 85, Linköping, Sweden

    Johannes D. Johansson, Ola Eriksson & Karin Wårdell

  2. Elekta Instrument AB, Stockholm, Sweden

    Ola Eriksson

  3. Department of Mechanical Engineering, Linköping University, Linköping, Sweden

    Joakim Wren & Dan Loyd

Authors
  1. Johannes D. Johansson
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  2. Ola Eriksson
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  3. Joakim Wren
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  4. Dan Loyd
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  5. Karin Wårdell
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Corresponding author

Correspondence to Johannes D. Johansson.

Additional information

This work was supported by The Swedish Research Council (Vetenskapsrådet, No. 621-2002-5772) and NIMED (Competence Center Noninvasive Medical Measurements).

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Johansson, J.D., Eriksson, O., Wren, J. et al. Radio-frequency lesioning in brain tissue with coagulation-dependent thermal conductivity: modelling, simulation and analysis of parameter influence and interaction. Med Bio Eng Comput 44, 757–766 (2006). https://doi.org/10.1007/s11517-006-0098-1

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  • DOI: https://doi.org/10.1007/s11517-006-0098-1

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