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Assessment of Endothelial Function Using Arterial Pressure Signals

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Abstract

Peripheral arterial tonometry (PAT) is a useful method to assess endothelial function. Analysis of pulse wave amplitude with PAT during reactive hyperemia can be used to study peripheral vascular endothelial function very well. We had injected a specific nitric oxide (NO) synthesize inhibitor intra-arterially into five adult male rats to verify the validation of our proposed photoplethysmograpy (PPG) system for endothelial function assessment. However, the reproducibility was not good for the system applied for measuring fingertip peripheral arteries. Therefore, an air-pressure sensing system with the high reproducibility was developed for peripheral vascular endothelial function assessment. This study showed that the vasodilatation index measured with air-pressure sensing system correlated very well with that measured using peripheral arterial tonometry. In addition, only few minutes are needed for conducting a self endothelial function assessment at home. And, early self-monitoring of cardiovascular dysfunction and arterial stiffness can be easily and effectively achieved.

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Acknowledgment

This research was supported by the National Science Council under Grant NSC 97-2221-E-259-019, Taiwan, Republic of China.

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Authors and Affiliations

  1. Department of Electrical Engineering, National Dong-Hwa University, No. 1, Sec. 2, Da-Hsueh Rd., Shoufeng, Hualien, Taiwan, 97401

    Hsien-Tsai Wu, Chun-Ho Lee & An-Bang Liu

  2. Department of Neurology, Buddhist Tzu Chi General Hospital and Buddhist Tzu Chi University, No. 707, Sec. 3, Chung-Yang Rd., Hualien, Taiwan

    An-Bang Liu

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  1. Hsien-Tsai Wu
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Correspondence to Hsien-Tsai Wu.

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Wu, HT., Lee, CH. & Liu, AB. Assessment of Endothelial Function Using Arterial Pressure Signals. J Sign Process Syst 64, 223–232 (2011). https://doi.org/10.1007/s11265-009-0431-7

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  • DOI: https://doi.org/10.1007/s11265-009-0431-7

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