Abstract
Magnetic resonance imaging is a widely used medical imaging technology, which can provide different contrasts between the tissues in human body. To use the complementary information from multiple imaging modalities and shorten the time of MR scanning, cross-modality magnetic resonance image synthesis has recently aroused extensive interests in literature. Most existing methods improve the quality of image synthesis by artificially designing loss on the basis of minimizing pixel-wise intensity error, even though it can improve the quality of the synthesized image, it is still difficult to balance the hyperparameters of different loss functions. In this paper, we propose a generative adversarial network (Trans-cGAN) based on transformer and unet for cross-modality magnetic resonance image synthesis. Specifically, transformer block is added into the network to enhance the model’s understanding of the overall semantics of the image as well as to implicitly integrate the edge information. Moreover, spectral normalization is added to the generator and discriminator to avoid mode collapse and ensure the stability of training. Experimental results demonstrate that the proposed Trans-cGAN is superior to the most of the cross-modality MR image synthesis methods in both qualitative and quantitative evaluations. Furthermore, Trans-cGAN also shows excellent generality in the generic image synthesis task of the benchmark datasets of maps and cityscapes.
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Funding
Financial support:The work was supported by grands from the National Natural Science Foundation of China (No. 11971214, 81960309).
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YL: Conceptualization, data curation, methodology, software, writing—original draft. NH: Resources, data curation. YQ: Data curation. JZ: Validation, supervision. JS: Validation, supervision, writing—review and editing. All authors reviewed the manuscript.
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All experimental protocols were approved by Medical Ethics Committee of Lanzhou University Second Hospital (approval number: 2022A-650, dated 20 October 2022), all methods were carried out in accordance with relevant guidelines and regulations.
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Li, Y., Han, N., Qin, Y. et al. Trans-cGAN: transformer-Unet-based generative adversarial networks for cross-modality magnetic resonance image synthesis. Stat Comput 33, 113 (2023). https://doi.org/10.1007/s11222-023-10282-8
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DOI: https://doi.org/10.1007/s11222-023-10282-8