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Metabolism Serves as a Bridge Between Cardiomyocytes and Immune Cells in Cardiovascular Diseases

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Abstract

Metabolic disorders of cardiomyocytes play an important role in the progression of various cardiovascular diseases. Metabolic reprogramming can provide ATP to cardiomyocytes and protect them during diseases, but this transformation also leads to adverse consequences such as oxidative stress, mitochondrial dysfunction, and eventually aggravates myocardial injury. Moreover, abnormal accumulation of metabolites induced by metabolic reprogramming of cardiomyocytes alters the cardiac microenvironment and affects the metabolism of immune cells. Immunometabolism, as a research hotspot, is involved in regulating the phenotype and function of immune cells. After myocardial injury, both cardiac resident immune cells and heart-infiltrating immune cells significantly contribute to the inflammation, repair and remodeling of the heart. In addition, metabolites generated by the metabolic reprogramming of immune cells can further affect the microenvironment, thereby affecting the function of cardiomyocytes and other immune cells. Therefore, metabolic reprogramming and abnormal metabolite levels may serve as a bridge between cardiomyocytes and immune cells, leading to the development of cardiovascular diseases. Herein, we summarize the metabolic relationship between cardiomyocytes and immune cells in cardiovascular diseases, and the effect on cardiac injury, which could be therapeutic strategy for cardiovascular diseases, especially in drug research.

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Funding

This work was supported by the National Natural Science Foundation of China (81902136), Chinese Postdoctoral Science Foundation (2019M660106), and the Natural Science Foundation of the Jiangsu Higher Education Institutions of China (20KJA310006).

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  1. Department of Laboratory Medicine, Affiliated Hospital of Jiangsu University, No. 438 Jiefang Road, Zhenjiang, 212001, China

    Lixiao Hang & Lin Xia

  2. Department of Biochemistry and Molecular Biology, School of Medicine, Jiangsu University, Zhenjiang, 212013, China

    Ying Zhang

  3. International Genome Center, Jiangsu University, Zhenjiang, 212013, China

    Lixiao Hang & Zheng Zhang

  4. Department of Laboratory Medicine, Jiangyin Hospital of Traditional Chinese Medicine, No.130 Renmin Middle Road, Wuxi, 214400, Jiangyin, China

    Haiqiang Jiang

  5. Institute of Hematological Disease, Jiangsu University, Zhenjiang, 212001, China

    Lin Xia

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Hang, L., Zhang, Y., Zhang, Z. et al. Metabolism Serves as a Bridge Between Cardiomyocytes and Immune Cells in Cardiovascular Diseases. Cardiovasc Drugs Ther (2024). https://doi.org/10.1007/s10557-024-07545-5

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