A spatial stochastic neuronal model with Ornstein–Uhlenbeck input current

 We consider a spatial neuron model in which the membrane potential satisfies a linear cable equation with an input current which is a dynamical random process of the Ornstein–Uhlenbeck (OU) type. This form of current may represent an approximation to that resulting from the random opening and closing of ion channels on a neuron's surface or to randomly occurring synaptic input currents with exponential decay. We compare the results for the case of an OU input with those for a purely white-noise-driven cable model. The statistical properties, including mean, variance and covariance of the voltage response to an OU process input in the absence of a threshold are determined analytically. The mean and the variance are calculated as a function of time for various synaptic input locations and for values of the ratio of the time constant of decay of the input current to the time constant of decay of the membrane voltage in the physiological range for real neurons. The limiting case of a white-noise input current is obtained as the correlation time of the OU process approaches zero. The results obtained with an OU input current can be substantially different from those in the white-noise case. Using simulation of the terms in the series representation for the solution, we estimate the interspike interval distribution for various parameter values, and determine the effects of the introduction of correlation in the synaptic input stochastic process.

Authors and Affiliations

1. Department of Mathematics, University of California, Irvine, California 92697, USA, , , , , , US

   Henry C. Tuckwell & Frederic Y. M. Wan

2. Laboratoire de Biométrie, INRA, Route de St Cyr, 78026 Versailles Cedex, France, , , , , , FR

   Jean-Pierre Rospars

Received: 5 March 2001 / Accepted in revised form: 7 August 2001

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