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The CBL–CIPK network mediates different signaling pathways in plants

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Abstract

The calcineurin B-like protein–CBL-interacting protein kinase (CBL–CIPK) signaling pathway in plants is a Ca2+-related pathway that responds strongly to both abiotic and biotic environmental stimuli. The CBL–CIPK system shows variety, specificity, and complexity in response to different stresses, and the CBL–CIPK signaling pathway is regulated by complex mechanisms in plant cells. As a plant-specific Ca2+ sensor relaying pathway, the CBL–CIPK pathway has some crosstalk with other signaling pathways. In addition, research has shown that there is crosstalk between the CBL–CIPK pathway and the low-K+ response pathway, the ABA signaling pathway, the nitrate sensing and signaling pathway, and others. In this paper, we summarize and review research discoveries on the CBL–CIPK network. We focus on the different modification and regulation mechanisms (phosphorylation and dephosphorylation, dual lipid modification) of the CBL–CIPK network, the expression patterns and functions of CBL–CIPK network genes, the responses of this network to abiotic stresses, and its crosstalk with other signaling pathways. We also discuss the technical research methods used to analyze the CBL–CIPK network and some of its newly discovered functions in plants.

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Abbreviations

CBL:

Calcineurin B-like protein

CIPK:

CBL-interacting protein kinase

CaM:

Calmodulin

CDPK:

Ca2+-dependent protein kinase

AMPK:

AMP-activated protein kinase

PPI:

Protein phosphatase interaction motif

SNF1:

Sucrose non-fermenting 1

PP2C:

Class 2C protein phosphatase

ABI1/2/3/4/5:

ABA-insensitive protein 1/2/3/4/5

PFPF/FISL motif:

Indicated amino acids conserved in each motif

NtSar1:

Secretion-associated Ras-related protein 1 of Nicotiana tabacum

BFA:

Brefeldin A

ROS:

Reactive oxygen species

SOS:

Salt overly sensitive

HKT:

High-affinity K+-transporter

AKT:

Arabidopsis K+ transporter

AHA2:

Arabidopsis H+ ATPase 2

EF-hand:

Elongation factor-hand

MAPK:

Mitogen-activated protein kinase

GA:

Gibberellin

ABA:

Abscisic acid

Rboh:

Respiratory burst oxidase homolog

PM:

Plasma membrane

ER:

Endoplasmic reticulum

Sub1A:

Submergene 1A

SnRK:

SNF1 (sucrose non-fermenting-1)-related protein kinase

OST1:

Open stomata 1

ABRE:

ABA-responsive element

AREB:

ABRE-binding protein

LEA:

Late embryogenesis abundant

PYR:

Pyrabactin resistance

PYL:

PYR 1-like

TF:

Transcription factor

RCAR:

Regulatory component of ABA receptor

Y2H:

Yeast two-hybrid method

SUS:

Mating-based split-ubiquitin system

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Authors and Affiliations

  1. School of Life Science and Biotechnology, Dalian University of Technology, Linggong Road No. 2, Dalian, Liaoning, China

    Qinyang Yu, Lijia An & Wenli Li

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  1. Qinyang Yu
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  2. Lijia An
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  3. Wenli Li
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Correspondence to Wenli Li.

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Communicated by N. Stewart.

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Yu, Q., An, L. & Li, W. The CBL–CIPK network mediates different signaling pathways in plants. Plant Cell Rep 33, 203–214 (2014). https://doi.org/10.1007/s00299-013-1507-1

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  • DOI: https://doi.org/10.1007/s00299-013-1507-1

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