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Dendritic cells as gatekeepers of tolerance

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Abstract

Dendritic cells (DC) are unique hematopoietic cells, linking innate and adaptive immune responses. In particular, they are considered as the most potent antigen presenting cells, governing both T cell immunity and tolerance. In view of their exceptional ability to present antigen and to interact with T cells, DC play distinct roles in shaping T cell development, differentiation and function. The outcome of the DC-T cell interaction is determined by the state of DC maturation, the type of DC subset, the cytokine microenvironment and the tissue location. Both regulatory T cells (Tregs) and DC are indispensable for maintaining central and peripheral tolerance. Over the past decade, accumulating data indicate that DC critically contribute to Treg differentiation and homeostasis.

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Acknowledgments

We thank Tommy Regen, Ronald Backer and Julia Ober-Blöbaum for critical reading of the manuscript. Research that is relevant for this review is and has been supported by grants from, respectively, the DFG (SFB TR128 and TR156 to AW) and the NWO (VIDI 917-76-365 to BEC) as well as by the Forschungszentrum für Immuntherapie (FZI) Mainz.

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Authors and Affiliations

  1. Institute for Molecular Medicine, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany

    Ari Waisman, Dominika Lukas, Björn E. Clausen & Nir Yogev

  2. Department of Microbiology, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany

    Dominika Lukas

  3. Department of Neurology, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany

    Nir Yogev

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  1. Ari Waisman
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  2. Dominika Lukas
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  3. Björn E. Clausen
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Correspondence to Ari Waisman.

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This article is a contribution to the special issue on Dendritic Cell Subsets and Immune-mediated Diseases - Guest Editor: Francisco Quintana

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Waisman, A., Lukas, D., Clausen, B.E. et al. Dendritic cells as gatekeepers of tolerance. Semin Immunopathol 39, 153–163 (2017). https://doi.org/10.1007/s00281-016-0583-z

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