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Application of nanoparticles in breast cancer treatment: a systematic review

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Abstract

It is estimated that cancer is the second leading cause of death worldwide. The primary or secondary cause of cancer-related mortality for women is breast cancer. The main treatment method for different types of cancer is chemotherapy with drugs. Because of less water solubility of chemotherapy drugs or their inability to pass through membranes, their body absorbs them inadequately, which lowers the treatment’s effectiveness. Drug specificity and pharmacokinetics can be changed by nanotechnology using nanoparticles. Instead, targeted drug delivery allows medications to be delivered to the targeted sites. In this review, we focused on nanoparticles as carriers in targeted drug delivery, their characteristics, structure, and the previous studies related to breast cancer. It was shown that nanoparticles could reduce the negative effects of chemotherapy drugs while increasing their effectiveness. Lipid-based nanocarriers demonstrated notable results in this instance, and some products that are undergoing various stages of clinical trials are among the examples. Nanoparticles based on metal or polymers demonstrated a comparable level of efficacy. With the number of cancer cases rising globally, many researchers are now looking into novel treatment approaches, particularly the use of nanotechnology and nanoparticles in the treatment of cancer. In order to help clinicians, this article aimed to gather more information about various areas of nanoparticle application in breast cancer therapy, such as modifying their synthesis and physicochemical characterization. It also sought to gain a deeper understanding of the mechanisms underlying the interactions between nanoparticles and biologically normal or infected tissues.

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(Source: Ahmad et al. 2021)

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Data Availability

No datasets were generated or analysed during the current study.

Abbreviations

Ag NPs:

Silver NPs

AmPDs:

Amphiphilic peptide dendrimers

Au NPs:

Gold nanoparticles

BC:

Breast cancer

Bio-AgNPs:

Biologically produced silver nanoparticles

bPEI:

Branched polyethyleneimine

CDs:

Carbon dots

CDT:

Chemodynamic therapy

Ce6:

Chlorin e6

CET:

Cetuximab

CMNPs:

Citric acid-coated magnetic iron oxide nanoparticles

CNTs:

Carbon nanotubes

CPT:

Camptothecin

CQDs:

Carbon quantum dots

CS:

Chitosan

CuGII:

Graphene oxide/Cu (II)

CuNPs:

Copper nanoparticles

CUR:

Curcumin

DDS:

Drug delivery systems

DFT:

Density functional theory

DMMA:

2,3-Dimethylmaleic anhydride

DOX:

Doxorubicin

DPTL:

Dipentaerythritol

EGFR:

Epidermal growth factor receptor

EPR:

Enhanced permeability and retention

ER:

Estrogen receptor

FA:

Folic acid

FasR:

Fas receptor

Gnb:

Gefitinib-loaded cellulose acetate butyrate

GO:

Graphene oxide

GSH:

Glutathione

HA:

Hyaluronic acid

HA:

Hydroxyapatite

HCC:

Hepatocellular carcinoma

HER2:

Human epidermal growth factor-receptor 2

HR:

Hormone receptor

IC50:

Half-maximal inhibitory concentrations

IONPs:

Iron oxide nanoparticles

LHRH:

Hormone-releasing hormone

LMD:

Hydrophobic polymer/lipid-MnO2

LNPs:

Lipid nanoparticles

LPO:

Lipid peroxidation

LSH:

Liposome-silica hybrid

LTN:

Luteolin

Mdoc:

Molecular docking

MET:

Metformin

MNPs:

Magnetic nanoparticles

MNPs:

Metal nanoparticles

MRI:

Magnetic resonance imaging

MSNPs:

Mesoporous silica nanoparticles

MT:

Metallothionein

MTX:

Methotrexate

MDR:

Multidrug resistance

MWCNT:

Multi-walled carbon nanotubes

NIR:

Near-infrared light

NLCs:

Nanostructured lipid carriers

NMR:

Nuclear magnetic resonance

NPs:

Nanoparticles

NZVI:

Nanoscale zero-valent iron

OS:

Median overall survival

PAMAM:

Polyamidoamine dendrimers

PBA:

Phenylboronic acid

PDA:

Polydopamine

pDNAs:

Plasmid deoxynucleic acids

PDT:

Photodynamic therapy

PEG:

Polyethylene glycol

PEI-FA:

Polyethyleneimine-folic acid

PLAL:

Pulsed laser ablation in liquid

PLGA:

Polylactic-co-glycolic acid

PLL:

Polylysine

PMD:

Polyelectrolyte-MnO2

PNPs:

Polymeric nanoparticles

PPGP:

Pyrrole polypropylene glycol

TNBC:

Triple-negative breast cancer

TRZ:

Radiolabeled trastuzumab

TSLs:

Thermosensitive liposomes

US:

Ultrasound

MNPs:

Magnetic nanoparticles

MNPs:

Metal nanoparticles

MRI:

Magnetic resonance imaging

MSNPs:

Mesoporous silica nanoparticles

MT:

Metallothionein

MTX:

Methotrexate

MDR:

Multidrug resistance

MWCNTs:

Multi-walled carbon nanotubes

NIR:

Near-infrared light

NLCs:

Nanostructured lipid carriers

NMR:

Nuclear magnetic resonance

NPs:

Nanoparticles

NZVI:

Nanoscale zero-valent iron

OS:

Median overall survival

PAMAM:

Polyamidoamine dendrimers

PBA:

Phenylboronic acid

PDA:

Polydopamine

pDNAs:

Plasmid deoxynucleic acids

PDT:

Photodynamic therapy

PEG:

Polyethylene glycol

PEI-FA:

Polyethyleneimine-folic acid

PLAL:

Pulsed laser ablation in liquid

PLGA:

Polylactic-co-glycolic acid

PLL:

Polylysine

PMD:

Polyelectrolyte-MnO2

PNPs:

Polymeric nanoparticles

PPGP:

Pyrrole polypropylene glycol

PPI:

Poly(propyleneimine)

PR:

Progesterone receptor

PS:

Photosensitizers

PTL:

Pentaerythritol

PTX:

Paclitaxel

PVC:

Polyvinyl chloride

QDs:

Quantum dots

qRT-PCR:

Quantitative real-time PCR

ROS:

Reactive oxygen species

SDT:

Sonodynamic therapy

SEM:

Scanning electron microscopy

siRNAs:

Small interfering ribonucleic acids

SLNs:

Solid lipid nanoparticles

SNPs:

Silica nanoparticles

SOD:

Superoxide dismutase

SPION:

Superparamagnetic iron oxide nanoparticles

SWCNTs:

Single-walled carbon nanotubes

TF:

Transferrin

THC:

Tetrahydro curcumin

TiO2:

Titanium dioxide

TMD:

Terpolymer/protein-MnO2

UV:

Ultraviolet

Vitamin E TPGS or TPGS:

D-ɑ-tocopheryl polyethylene glycol succinate

WHO:

World Health Organization

ZnO NPs:

Zinc NPs

α-TOS:

α-Tocopheryl succinate

TME:

Tumor microenvironment

qRT-PCR:

Quantitative real-time PCR

ROS:

Reactive oxygen species

SDT:

Sonodynamic therapy

SEM:

Scanning electron microscopy

siRNAs:

Small interfering ribonucleic acids

SLNs:

Solid lipid nanoparticles

SNPs:

Silica nanoparticles

SOD:

Superoxide dismutase

SPION:

Superparamagnetic iron oxide nanoparticles

SWCNTs:

Single-walled carbon nanotubes

TF:

Transferrin

THC:

Tetrahydro curcumin

TiO2:

Titanium dioxide

TMD:

Terpolymer/protein-MnO2

TME:

Tumor microenvironment

PPI:

Poly(propyleneimine)

PR:

Progesterone receptor

PS:

Photosensitizers

PTL:

Pentaerythritol

PTX:

Paclitaxel

PVC:

Polyvinyl chloride

QDs:

Quantum dots

References

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Author information

Authors and Affiliations

  1. Department of Agronomy and Plant Breeding, Faculty of Agriculture and Natural Resources, University of Mohaghegh Ardabili, Ardabil, Iran

    Shima Bourang, Mehran Noruzpour, Sodabeh Jahanbakhsh Godekahriz , Amin Amani & Rasool Asghari Zakaria

  2. Department of Pharmaceutics, School of Pharmacy, Ardabil University of Medical Sciences, Ardabil, Iran

    Hossein Ali Ca Ebrahimi

  3. Department of Biology, Ardabil Branch, Islamic Azad University, Ardabil, Iran

    Hashem Yaghoubi

Authors
  1. Shima Bourang
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  2. Mehran Noruzpour
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  3. Sodabeh Jahanbakhsh Godekahriz
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  4. Hossein Ali Ca Ebrahimi
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  5. Amin Amani
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  6. Rasool Asghari Zakaria
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  7. Hashem Yaghoubi
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Contributions

Shima and Hossein Ali hypothesizad the idea of this manuscript. Shima and Mehran prepared the initial design of this review article. All the members of the group prepared the contents of different sections together with the coordinator. Sodabeh and Hossein Ali have designed the figures, and Amin helped in answering in review process of the article. Shima and Rasool proofread the final version of the article. All authors read and approved the manuscript. The authors confirm that no paper mill and artificial intelligence was used.

Corresponding author

Correspondence to Hossein Ali Ca Ebrahimi.

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Bourang, S., Noruzpour, M., Jahanbakhsh Godekahriz , S. et al. Application of nanoparticles in breast cancer treatment: a systematic review. Naunyn-Schmiedeberg's Arch Pharmacol 397, 6459–6505 (2024). https://doi.org/10.1007/s00210-024-03082-y

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