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Lactic acidosis

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Fig. 1.

References

  1. Levy B, Sadoune LO, Gelot AM, Bollaert PE, Nabet P, Larcan A (2000) Evolution of lactate/pyruvate and arterial ketone body ratios in the early course of catecholamine-treated septic shock. Crit Care Med 28:114–119

    Article  CAS  Google Scholar 

  2. Stacpoole PW, Wright EC, Baumgartner TG, Bersin RM, Buchalter S, Curry SH, Duncan CA, Harman EM, Henderson GN, Jenkinson S (1992) A controlled clinical trial of dichloroacetate for treatment of lactic acidosis in adults. The Dichloroacetate-Lactic Acidosis Study Group. N Engl J Med 327:1564–1569

    Article  CAS  Google Scholar 

  3. Gore DC, Jahoor F, Hibbert JM, DeMaria EJ (1996) Lactic acidosis during sepsis is related to increased pyruvate production, not deficits in tissue oxygen availability. Ann Surg 224:97–102

    Article  CAS  Google Scholar 

  4. Bellomo R, Kellum JA, Pinsky MR (1996) Transvisceral lactate fluxes during early endotoxemia. Chest 110:198–204

    Article  CAS  Google Scholar 

  5. De Backer D, Creteur J, Zhang H, Norrenberg M, Vincent JL (1997) Lactate production by the lungs in acute lung injury. Am J Respir Crit Care Med 156:1099–1104

    Article  Google Scholar 

  6. De Backer D, Creteur J, Silva E, Vincent JL (2001) The hepatosplanchnic area is not a common source of lactate in patients with severe sepsis. Crit Care Med 29:256–261

    Article  Google Scholar 

  7. Haji-Michael PG, Ladriere L, Sener A, Vincent JL, Malaisse WJ (1999) Leukocyte glycolysis and lactate output in animal sepsis and ex vivo human blood. Metabolism 48:779–785

    Article  CAS  Google Scholar 

  8. Levraut J, Ciebiera JP, Chave S, Rabary O, Jambou P, Carles M, Grimaud D (1998) Mild hyperlactatemia in stable septic patients is due to impaired lactate clearance rather than overproduction. Am J Respir Crit Care Med 157:1021–1026

    Article  CAS  Google Scholar 

  9. Weil MH, Afifi AA (1970) Experimental and clinical studies on lactate and pyruvate as indicators of the severity of acute circulatory failure (shock). Circulation 41:989–1001

    Article  CAS  Google Scholar 

  10. Rivers E, Nguyen B, Havstadt S, Ressler J, Muzzin A, Knoblich B, Peterson E, Tomlanovich M (2001) Early goal-directed therapy in the treatment of severe sepsis and septic shock. N Engl J Med 345:1368–1377

    Article  CAS  Google Scholar 

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Correspondence to Daniel De Backer.

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De Backer, D. Lactic acidosis. Intensive Care Med 29, 699–702 (2003). https://doi.org/10.1007/s00134-003-1746-7

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  • DOI: https://doi.org/10.1007/s00134-003-1746-7

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