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Role of glutathione in selenite binding by human plasma

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Abstract

The erythrocyte-mediated reduction of selenite has been reproduced by the addition of reduced glutathione to plasma at levels comparable to those present in the erythrocyte. The reaction has been followed by chromatography and ultraviolet (UV) absorption spectroscopy (in the absence of plasma). The first detectable compound, selenium diglutathione, is very unstable in physiological conditions. The product of the reaction does not contain glutathione and is able to react and incorporate selenium into plasma proteins without the participation of hemoglobin or glutathione reductase. A saturable low molecular weight compound is also able to bind selenium, which may be relevant in the initial distribution and excretion of selenium after selenite administration.

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Authors and Affiliations

  1. Research Institute, The Hospital for Sick Children, M5G 1X8, Toronto, Ontario

    Alberto Mas & Bibudhendra Sarkar

  2. Dept. of Biochemistry, University of Toronto, M5S 1A8, Toronto, Ontario, Canada

    Alberto Mas & Bibudhendra Sarkar

Authors
  1. Alberto Mas
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  2. Bibudhendra Sarkar
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Mas, A., Sarkar, B. Role of glutathione in selenite binding by human plasma. Biol Trace Elem Res 20, 95–104 (1989). https://doi.org/10.1007/BF02919102

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  • DOI: https://doi.org/10.1007/BF02919102

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