Abstract
Effective electrical size (ratio of ventricular size to electrical activation wavelength) plays a significant role in governing reentrant arrhythmia dynamics. Due to similarities in effective size with the human, the rabbit has been suggested as the most useful experimental model for clinical investigations of fibrillatory arrhythmias. However, how well the effective size of the rabbit, or other small mammalians, correlates to the human during slower pacing rates (such as those often seen during anatomical scar-related reentrant arrhythmias), and importantly how it varies with frequency, is currently not well understood. We used computational ionic ventricular cell models of human, rabbit, rat and guinea pig to investigate interspecies differences in action potential duration, conduction velocity and activation wavelength restitution, and how these combine together to induce important rate-dependant variations in effective size. We conclude that the rabbit model has a closer effective electrical size to the human across a range of activation rates, although differences in effective size dynamics are seen at high frequencies. This suggests potentially important differences in the initiation and anchoring of reentrant waves around anatomical structures, highlighting the need for further investigation of the utility of such models for informing clinical scar-related arrhythmia knowledge.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Similar content being viewed by others
References
Lim, Z., Maskara, B., Aguel, F., Emokpae, R.: Spiral wave attachment to millimeter-sized obstacles. Circulation 114, 2113–2121 (2006)
Lou, Q., Efimov, I.: The role of dynamic instability and wavelength in arrhythmia maintenance as revealed by panoramic imaging with blebbistatin vs. 2,3-butanedione monoxime. AJP Heart Circ. Phys. 302, 262–269 (2012)
Bishop, M., Plank, G.: The role of fine-scale anatomical structure in the dynamics of reentry in computational models of the rabbit ventricles. J. Physiol. 590, 4515–4535 (2012)
Ripplinger, C., Lou, Q., Efimov, I.: Panoramic imaging reveals basic mechanisms of induction and termination of ventricular tachycardia in rabbit heart with chronic infarction: implications for low-voltage cardioversion. Heart Rhy. 6, 87–97 (2009)
Panfilov, A.: Is heart size a factor in ventricular fibrillation? or how close are rabbit and human hearts? Heart Rhythm 3, 862–864 (2006)
ten Tusscher, K., Panfilov, A.: Alternans and spiral breakup in a human ventricular tissue model. AJP Heart and Circ. Phys. 291, 1088–1100 (2006)
Mahajan, A., Shiferaw, Y., Sato, D., Baher, A., Olcese, R., Xie, L., Yang, M., Chen, P., Restrepo, J., Karma, A., Garfinkel, A., Qu, Z., Weiss, J.: A rabbit ventricular action potential model replicating cardiac dynamics at rapid heart rates. Biophys. J. 94, 392–410 (2008)
Luo, C., Rudy, Y.: A dynamic model of the cardiac ventricular action potential i. simulations of ionic currents and concentration changes. Circ. Res. 74, 1071–1096 (1994)
Pandit, S., Clark, R., Giles, W., Demir, S.: A mathematical model of action potential heterogeneity in adult rat left ventricular myocytes. Biophys. J. 81, 3029–3051 (2001)
Vigmond, E., Hughes, M., Plank, G., Leon, L.: Computational tools for modeling electrical activity in cardiac tissue. J. Electrocardiol. 36, 69–74 (2003)
Clerc, L.: Directional differences of impulse spread in trabecular muscle from mammalian heart. J. Physiol. 255, 335–346 (1976)
Shigematsu, S., Kiyosue, T., Sato, T., Arita, M.: Rate-dependent prolongation of action potential duration in isolated rat ventricular myocytes. Basic. Res. Cardiol. 92, 123–128 (1997)
Benoist, D., Stones, R., Drinkhill, M., Benson, A., Yang, Z., Cassan, C., Gilbert, S., Saint, D., Cazorla, O., Steele, D., Bernus, O., White, E.: Cardiac arrhythmia mechanisms in rats with heart failure induced by pulmonary hypertension. AJP Heart and Circ. Phys. 302, 2381–2395 (2012)
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2013 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Hill, Y., Plank, G., Smith, N., Bishop, M. (2013). Comparison of Changes in Effective Electrical Size with Activation Rate between Small Mammalian and Human Ventricular Models. In: Ourselin, S., Rueckert, D., Smith, N. (eds) Functional Imaging and Modeling of the Heart. FIMH 2013. Lecture Notes in Computer Science, vol 7945. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-38899-6_7
Download citation
DOI: https://doi.org/10.1007/978-3-642-38899-6_7
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-38898-9
Online ISBN: 978-3-642-38899-6
eBook Packages: Computer ScienceComputer Science (R0)