Abstract
The purpose of this paper is to compare subregional breast density and whole breast density and their association with breast cancer risk. The film mammograms of 278 cases and 834 age and ethnicity-matched controls were digitized and analyzed using single-energy x-ray absorptiometry (SXA). The subregion was a 3-cm diameter circle centered in the breast. The whole and subregional densities are found to be highly correlated (r2=0.7). The 4:1 quartile odds ratio after controlling for other significant risk factors (age, BMI, family history and age at first live birth) was 3.6 (95 CI 2.1-5.4) and the 2.4 (95 CI 1.5-3.7) for the whole and subregional breast density, respectively. Further studies are underway to optimize the placement of the ROI and combined multiple regions.
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Malkov, S., Ma, L., Kerlikowske, K., Wang, J., Cummings, S., Shepherd, J. (2010). Comparison of Subregional Breast Density with Whole Breast Density. In: Martí, J., Oliver, A., Freixenet, J., Martí, R. (eds) Digital Mammography. IWDM 2010. Lecture Notes in Computer Science, vol 6136. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-13666-5_54
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DOI: https://doi.org/10.1007/978-3-642-13666-5_54
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-13665-8
Online ISBN: 978-3-642-13666-5
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