Abstract
Various interactions of human immunodeficiency virus type 1 (HIV-1) proteins with those of the host cell are known, but a large-scale network encompassing all known interactions of HIV-1 proteins and host cell proteins have not been analyzed or visualized. This is partly because large-scale interaction data are not readily available from public databases and individual literatures report small-scale interactions. NCBI recently released a database of all known interactions of HIV-1 proteins and human proteins. Now, a challenging task is to analyze all the interactions in a systematic way and to identify biologically meaningful interaction groups or patterns. This paper presents the development of a web-based system (http://hiv1.hpid.org) for visualizing and analyzing the large-scale interactions between HIV-1 and human proteins and the comparative analysis of the interactions. The whole interaction network contains 1,768 interactions of 65 different types with 810 human proteins. The analysis identified several interesting interaction groups from the comparative analysis of the interaction networks.
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Han, K., Park, B. (2007). Comparative Analysis of the Interaction Networks of HIV-1 and Human Proteins. In: Shi, Y., van Albada, G.D., Dongarra, J., Sloot, P.M.A. (eds) Computational Science – ICCS 2007. ICCS 2007. Lecture Notes in Computer Science, vol 4488. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-72586-2_49
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DOI: https://doi.org/10.1007/978-3-540-72586-2_49
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-72585-5
Online ISBN: 978-3-540-72586-2
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