Abstract
Cardiac remodelling, which refers to the change of the shape and size of the myocardium, is an adaptive response to developmental, disease and surgical processes. Traditional metrics of length, volume, aspect ratio or wall thickness are used in the clinic and in medical research, but have limited capabilities to describe complex structures such as the shape of cardiac ventricles. In this work we present an example of how computational analysis of cardiac anatomy can reveal more detailed description of developmental and remodelling patterns. The clinical problem is the analysis of the impact of two different surgical palliation techniques for hypoplastic left heart syndrome. Construction of a computational atlas and the statistical description of its variability are performed from the short axis stack of 128 subjects. Results unveil, for the first time in the literature, the differences in remodelling of the systemic right ventricle depending on the surgical palliation technique.
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Acknowledgements
This study has received funding by the Department of Health through the NIHR comprehensive Biomedical Research Centre award to Guy’s & St Thomas’ NHS Foundation Trust in partnership with King’s College London and King’s College Hospital NHS Foundation Trust, the Centre of Excellence in Medical Engineering (funded by the Wellcome Trust and EPSRC; grant number WT 088641/Z/09/Z) as well as the BHF Centre of Excellence (British Heart Foundation award RE/08/03). PL holds a Sir Henry Dale Fellowship funded jointly by the Wellcome Trust and the Royal Society (grant no. 099973/Z/12/Z).
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Zacur, E., Wong, J., Razavi, R., Geva, T., Greil, G., Lamata, P. (2015). Revealing Differences in Anatomical Remodelling of the Systemic Right Ventricle. In: van Assen, H., Bovendeerd, P., Delhaas, T. (eds) Functional Imaging and Modeling of the Heart. FIMH 2015. Lecture Notes in Computer Science(), vol 9126. Springer, Cham. https://doi.org/10.1007/978-3-319-20309-6_12
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DOI: https://doi.org/10.1007/978-3-319-20309-6_12
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