Abstract
Biofilms research has evolved considerably in the last decade and is now generating large volumes of heterogeneous data. MIABiE, the international initiative on Biofilms, is devising guidelines for data interchange, and some databases provide access to biofilms experiments. However, the field is lacking appropriate bioinformatics tools in support of increasing operational and analytical needs. This paper presents a flexible and extensible open-source workbench for the operation and analysis of biofilms experiments, as follows: (i) the creation of customised experiments, (ii) the collection of various analytical results, following community standardisation guidelines and (iii) on-demand reporting and statistical evaluation.
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Hall-Stoodley, L., Costerton, J.W., Stoodley, P.: Bacterial biofilms: from the natural environment to infectious diseases. Nat. Rev. Microbiol. 2, 95–108 (2004)
Donlan, R.M.: Biofilms: microbial life on surfaces. Emerg. Infect. Dis. 8, 881–890 (2002)
Davey, M.E., O’toole, G.A.: Microbial biofilms: from ecology to molecular genetics. Microbiol. Mol. Biol. Rev. 64, 847–867 (2000)
Jain, A., Gupta, Y., Agrawal, R., Khare, P., Jain, S.K.: Biofilms–a microbial life perspective: a critical review. Crit. Rev. Ther. Drug Carrier Syst. 24, 393–443 (2007)
Römling, U., Balsalobre, C.: Biofilm infections, their resilience to therapy and innovative treatment strategies. J. Intern. Med. 272, 541–561 (2012)
Peters, B.M., Jabra-Rizk, M.A., O’May, G.A., Costerton, J.W., Shirtliff, M.E.: Polymicrobial interactions: impact on pathogenesis and human disease. Clin. Microbiol. Rev. 25, 193–213 (2012)
Azevedo, N.F., Lopes, S.P., Keevil, C.W., Pereira, M.O., Vieira, M.J.: Time to “go large” on biofilm research: advantages of an omics approach. Biotechnol. Lett. 31, 477–485 (2009)
Buckingham-Meyer, K., Goeres, D.M., Hamilton, M.A.: Comparative evaluation of biofilm disinfectant efficacy tests. J. Microbiol. Methods 70, 236–244 (2007)
Hamilton, M.A.: KSA-SM-03 - Desirable attributes of a standardized method. Stand. METHODS Test. Surf. Disinfect (2010)
Lourenço, A., Ferreira, A., Veiga, N., Machado, I., Pereira, M.O., Azevedo, N.F.: BiofOmics: A Web Platform for the Systematic and Standardized Collection of High-Throughput Biofilm Data. PLoS One 7, e39960 (2012)
Sousa, A.M., Ferreira, A., Azevedo, N.F., Pereira, M.O., Lourenço, A.: Computational approaches to standard-compliant biofilm data for reliable analysis and integration. J. Integr. Bioinform. 9, 203 (2012)
Bray, T., Paoli, J., Sperberg-McQueen, C.M.: Extensible markup language, XML (1998), http://www.w3.org/TR/1998/REC-xml-19980210
Sreenivasaiah, P.K., Kim, D.H.: Current trends and new challenges of databases and web applications for systems driven biological research. Front. Physiol. 1, 147 (2010)
Glez-Peña, D., Reboiro-Jato, M., Maia, P., Rocha, M., Díaz, F., Fdez-Riverola, F.: AIBench: a rapid application development framework for translational research in biomedicine. Comput. Methods Programs Biomed. 98, 191–203 (2010)
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Rodríguez, G.P., Glez-Peña, D., Azevedo, N.F., Pereira, M.O., Fdez-Riverola, F., Lourenço, A. (2014). BEW: Bioinformatics Workbench for Analysis of Biofilms Experimental Data. In: Saez-Rodriguez, J., Rocha, M., Fdez-Riverola, F., De Paz Santana, J. (eds) 8th International Conference on Practical Applications of Computational Biology & Bioinformatics (PACBB 2014). Advances in Intelligent Systems and Computing, vol 294. Springer, Cham. https://doi.org/10.1007/978-3-319-07581-5_6
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DOI: https://doi.org/10.1007/978-3-319-07581-5_6
Publisher Name: Springer, Cham
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