Abstract
This paper presents an approach to cancer classification from gene expression profiling using cascaded neural network classifier. The method used aims to reduce the genes required to successfully classify the small round blue cell tumours of childhood (SRBCT) into four categories. The system designed to do this consists of a feedforward neural network and is trained with genetic algorithm. A concept of ‘gene masking’ is introduced to the system which significantly reduces the number of genes required for producing very high accuracy classification.
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Khan, J., Wei, J.S., Ringner, M., Saal, L.H., Ladanyi, M., Westermann, F., Berthold, F., Schwab, M., Antonescu, C.R., Perterson, C., Meltzer, P.S.: Classification and diagnostic prediction of cancers using gene expression profiling and artificial neural networks. Nature Medicine 7, 673–679 (2001)
Sarhan, A.M.: Cancer Classification based on Microarray Gene Expression DataUsing DCT and ANN. Journal of Theoretical and Applied Information Technology 6, 208–216 (2009)
Ghodsi, A.: Dimensionality Reduction A Short Tutorial. Technical Report 2006-14, Department of Statistics and Actuarial Science, University of Waterloo, Ontario, Canada, pp. 5–6 (2006)
Tibshirani, R., Hastie, T., Narasimhan, B., Chu, G.: Diagnosis of multiple cancer types by shrunken centroids of gene expression. Proceedings of the National Academy of Sciences 99, 6567–6572 (2002)
Rani, D.K.U.: Analysis of Heart Diseases Dataset Using Neural Network Approach. International Journal of Data Mining & Knowledge Management Process (IJDKP) 1 (2011)
Karsoliya, S.: Approximating Number of Hidden layer neurons in Multiple Hidden Layer BPNN Architecture. International Journal of Engineering Trends and Technology 3, 714–717 (2012)
Karlik, B., Olgac, A.V.: Performance Analysis of Various Activation Functions in Generalized MLP Architectures of Neural Networks. International Journal of Artificial Intelligence And Expert Systems 1, 111–122 (2011)
Singh, S., Chand, A., Lal, S.P.: Improving Spam Detection Using Neural Networks Trained by Memetic Algorithm. In: Proceedings of 5th IEEE International Conference on Computational Intelligence, Mathematical Modeling and Simulation, Seoul, Korea, pp. 55–60 (2013)
Goldberg, D.E.: Genetic Algorithms in Search, Optimization, and Machine Learning. Addison-Wesley (1989)
Bair, E., Tibshirani, R.: Machine Learning MethodsApplied to DNA Microarray Data Can Improve the Diagnosis of Cancer. Special Interest Group in Knowledge Discovery and Data Mining Explorations 5, 48–55 (2003)
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Kumar, R., Chand, K., Lal, S.P. (2014). Gene Reduction for Cancer Classification Using Cascaded Neural Network with Gene Masking. In: Sokolova, M., van Beek, P. (eds) Advances in Artificial Intelligence. Canadian AI 2014. Lecture Notes in Computer Science(), vol 8436. Springer, Cham. https://doi.org/10.1007/978-3-319-06483-3_29
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DOI: https://doi.org/10.1007/978-3-319-06483-3_29
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-06482-6
Online ISBN: 978-3-319-06483-3
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