Abstract
Intracranial aneurysms frequently cause subarachnoid hemorrhage—a life-threatening condition with a high mortality and morbidity rate. State-of-the-art methods combine demographic, clinical, morphological, and computational fluid dynamics parameters.
We propose a method combining morphological radiomics features, gray-level radiomics features, and a novel aneurysm site location encoding via directed graphs on the vessel tree. Some of the gray-level features seem to be good proxies for blood flow within the vessel and the aneurysms. Furthermore, our proposed method shows improved F2-scores and accuracy across various models fed with the aneurysm site encoding. A K-nearest neighbors method shows the best results during our model selection with an F2-score of 0.7 and an accuracy of 0.73 on the relatively small private test set with 22 individuals and 30 aneurysms.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Similar content being viewed by others
References
Teunissen, L.L., et al.: Risk Factors for Subarachnoid Hemorrhage (1996)
Can, A., et al.: Association of intracranial aneurysm rupture with smoking duration, intensity, and cessation (2017)
Chabert, S., et al.: Applying machine learning and image feature extraction techniques to the problem of cerebral aneurysm rupture (2017)
Detmer, F.J., et al.: Extending statistical learning for aneurysm rupture assessment to Finnish and Japanese populations using morphology, hemodynamics, and patient characteristics (2019)
Cebral, J.R., et al.: Analysis of hemodynamics and wall mechanics at sites of cerebral aneurysm rupture (2015)
Detmer, F.J., et al.: Associations of hemodynamics, morphology, and patient characteristics with aneurysm rupture stratified by aneurysm location (2019)
Thompson, B.G., et al.: Guidelines for the management of patients with unruptured intracranial aneurysms a guideline for healthcare professionals from the American heart association/American stroke association (2015)
Lindgren, A.E., et al.: Irregular shape of intracranial aneurysm indicates rupture risk irrespective of size in a population-based cohort (2016)
Tanioka, S., et al.: Machine learning classification of cerebral aneurysm rupture status with morphologic variables and hemodynamic parameters (2020)
Paliwal, N., et al.: Outcome prediction of intracranial aneurysm treatment by flow diverters using machine learning (2018)
Xiang, J., et al.: Hemodynamic–morphologic discriminants for intracranial aneurysm rupture (2011)
Suzuki, M., et al.: Classification model for cerebral aneurysm rupture prediction using medical and blood-flow-simulation data (2019)
Chen, G., et al.: Development and validation of machine learning prediction model based on computed tomography angiography-derived hemodynamics for rupture status of intracranial aneurysms: a Chinese multicenter study (2020)
Kleinloog, R., de Mul, N., Verweij, B.H., Post, J.A., Rinkel, G.J.E., Ruigrok, Y.M.: Risk Factors for intracranial aneurysm rupture: a systematic review (2018)
Chandra, A.R., et al.: Initial study of the radiomics of intracranial aneurysms using Angiographic Parametric Imaging (API) to evaluate contrast flow changes (2019)
Podgorsak, A.R., et al.: Automatic radiomic feature extraction using deep learning for angiographic parametric imaging of intracranial aneurysms (2020)
Liu, Q., Jiang, P., Jiang, Y., Li, S., Ge, H., Jin, H., Li, Y.: Bifurcation configuration is an independent risk factor for aneurysm rupture irrespective of location (2019)
Liu, Q., et al.: Prediction of aneurysm stability using a machine learning model based on pyradiomics-derived morphological features (2019)
Juchler, N., et al.: Radiomics approach to quantify shape irregularity from crowd-based qualitative assessment of intracranial aneurysms (2020)
CADA rupture risk estimation challenge. https://cada-rre.grand-challenge.org/. Accessed 05 Oct 2020
van Griethuysen, J.J.M., et al.: Computational radiomics system to decode the radiographic phenotype (2017)
Cetin, I.: A radiomics approach to computer-aided diagnosis with cardiac Cine-MRI (2017)
Wolterink, J.M., Leiner, T., Viergever, M.A., Išgum, I.: Automatic segmentation and disease classification using cardiac cine MR images (2017)
Khened, M., Alex, V., Krishnamurthi, G.: Densely connected fully convolutional network for short-axis cardiac cine MR image segmentation and heart diagnosis using random forest (2017)
Isensee, F., Jaeger, P.F., Full, P.M., Wolf, I., Engelhardt, S., Maier-Hein, K.H.: Automatic cardiac disease assessment on cine-MRI via time-series segmentation and domain specific features (2017)
Sugasawa, S., Noma, H.: Estimating individual treatment effects by gradient boosting trees (2019)
Akhil, J.: Prediction of heart disease using k-nearest neighbor and particle swarm optimization (2017)
Leo Breiman, Random Forests (2001)
Túlio Ribeiro, M., Singh, S., Guestrin, C.: Why should i trust you? Explaining the predictions of any classifier (2016)
Jiang, P.: A novel scoring system for rupture risk stratification of intracranial aneurysms: a hemodynamic and morphological study (2018)
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2021 Springer Nature Switzerland AG
About this paper
Cite this paper
Ivantsits, M., Huellebrand, M., Kelle, S., Kuehne, T., Hennemuth, A. (2021). Intracranial Aneurysm Rupture Risk Estimation Utilizing Vessel-Graphs and Machine Learning. In: Hennemuth, A., Goubergrits, L., Ivantsits, M., Kuhnigk, JM. (eds) Cerebral Aneurysm Detection and Analysis. CADA 2020. Lecture Notes in Computer Science(), vol 12643. Springer, Cham. https://doi.org/10.1007/978-3-030-72862-5_10
Download citation
DOI: https://doi.org/10.1007/978-3-030-72862-5_10
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-030-72861-8
Online ISBN: 978-3-030-72862-5
eBook Packages: Computer ScienceComputer Science (R0)