Abstract
At home genetic testing is currently accepted by a lot of people in many countries, and statistical data show that, currently, at home genetic testing has more than 26, 000, 000 customers all over the world. Generally, the business process for at home genetic testing is: after a user’s order, a saliva collection kit will be sent to the user, the user should split saliva to a specific saliva collection tube and send the kit back to laboratory, then the laboratory will extract the DNA from the saliva, and sequence the DNA using next generation sequencing equipment or micro-array platform, the generated DNA sequencing data will be analyzed and genetically interpreted, finally, a genetic report will be sent to the user. To handle millions of samples in a year requires a scalable, robust, parallel, and easy to use business process management system to satisfy the external customer service and internal sample track and management requirement. In this paper, we first describe the detail business process of at home genetic testing, then based on our best practice, using spring cloud, spring boot, and microservices, we give the design and implementation of a business process management platform to support at home genetic testing business. The platform is flexible that supports both the business to business service as well as the business to customer service.
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References
Sawczuka, M., Maciejewska, A., Cieszczyk, P., Eider, J.: The role of genetic research in sport. Sci. Sports 26(5), 251–258 (2011)
Guth, L.M., Roth, S.M.: Genetic influence on athletic performance. Curr Opin Pediatr. 25(6), 653–658 (2013)
U.S. Food and Drug Administration (FDA): Direct-to-Consumer Tests. https://www.fda.gov/medical-devices/vitro-diagnostics/direct-consumer-tests. Accessed 11 June 2019
Simopoulos, A.P.: The impact of the bellagio report on healthy agriculture, healthy nutrition, healthy people: scientific and policy aspects and the international network of centers for genetics, nutrition and fitness for health. J. Nutrigenet Nutrige. 7(4–6), 191–211 (2015)
Sales, N.M.R., Pelegrini, P.B., Goersch, M.C.: Nutrigenomics: definitions and advances of this new science. J. Nutr. Metab. 2014, 202759 (2014)
Makrantonaki, E., Bekou, V., Zouboulis, C.C.: Genetics and skin aging. Dermatoendocrinol 4(3), 280–284 (2012)
iScan System - Array scanner for extensive applications. https://www.illumina.com/systems/array-scanners/iscan.html. Accessed 11 June 2019
Gromadzka, G., et al.: Gene variants encoding proteins involved in antioxidant defense system and the clinical expression of Wilson disease. Liver Int. 35(1), 215–222 (2015)
Sanchez-Roige, S., et al.: Genome-wide association studies of impulsive personality traits (BIS-11 and UPPS-P) and drug experimentation in up to 22,861 adult research participants identify loci in the CACNA1I and CADM2 genes. J. Neurosci. 39(13), 2562–2572 (2019)
Lee, J.J., Wedow, R., Okbay, A., et al.: Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals. Nat. Genet. 50, 1112–1121 (2018)
Alexander, D.H., Novembre, J., Lange, K.: Fast model-based estimation of ancestry in unrelated individuals. Genome Res. 19(9), 1655–1664 (2009)
Nielsen, R., Paul, J.S., Albrechtsen, A., Song, Y.S.: Genotype and SNP calling from next-generation sequencing data. Nat. Rev. Genet. 12(6), 443–451 (2011)
U.S. National Library of Health: What are single nucleotide polymorphisms (SNPs)? https://ghr.nlm.nih.gov/primer/genomicresearch/snp. Accessed 11 June 2019
Hamosh, A., Scott, A.F., Amberger, J.S., Bocchini, C.A., McKusick, V.A.: Online Mendelian Inheritance in Man (OMIM), a knowledgebase of human genes and genetic disorders. Nucleic Acids Res. 33(Database issue), D514-7 (2005)
OMIM - Online Mendelian Inheritance in Man, an Online Catalog of Human Genes and Genetic Disorders. https://www.omim.org/. Accessed 11 June 2019
Pereanu, W., et al.: AutDB: a platform to decode the genetic architecture of autism. Nucleic Acids Res. 46(D1), D1049–D1054 (2018)
Fawcett, K.A., Barroso, I.: The genetics of obesity: FTO leads the way. Trends Genet. 26(6), 266–274 (2010)
Spring Cloud. https://spring.io/projects/spring-cloud. Accessed 11 June 2019
Spring Boot. https://spring.io/projects/spring-boot/. Accessed 11 June 2019
MyBatis. https://blog.mybatis.org/. Accessed 11 June 2019
The OAuth 2.0 Authorization Framework. https://tools.ietf.org/html/rfc6749. Accessed 11 June 2019
Vue - The Progressive JavaScript Framework. https://vuejs.org/. Accessed 11 June 2019
Tencent Cloud. https://intl.cloud.tencent.com/. Accessed 11 June 2019
Content Delivery Network. https://intl.cloud.tencent.com/product/cdn. Accessed 11 June 2019
WeChat. https://www.wechat.com/en/. Accessed 11 June 2019
Francesco, P.D., Malavolta. I., Lago, P.: Research on architecting microservices: trends, focus, and potential for industrial adoption. IEEE International Conference on Software Architecture (ICSA), Gothenburg, pp. 21–30 (2017)
Acknowledgment
This work was partially supported by the Science Foundation of Beijing Language and Culture University (supported by “the Fundamental Research Funds for the Central Universities”) (19YJ040010, 17YJ0302, 15YJ030001, 18YJ030006)
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Yang, J. (2019). At Home Genetic Testing Business Process Management Platform. In: Wang, H., Siuly, S., Zhou, R., Martin-Sanchez, F., Zhang, Y., Huang, Z. (eds) Health Information Science. HIS 2019. Lecture Notes in Computer Science(), vol 11837. Springer, Cham. https://doi.org/10.1007/978-3-030-32962-4_2
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DOI: https://doi.org/10.1007/978-3-030-32962-4_2
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